{"id":"W4406046327","doi":"10.2967/jnumed.124.267869","title":"Nuclear Cardiology Surrogate Biomarkers in Clinical Trials","year":2025,"lang":"en","type":"review","venue":"Journal of Nuclear Medicine","topic":"Cardiac Imaging and Diagnostics","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"British Heart Foundation","keywords":"Surrogate endpoint; Medicine; Clinical trial; Internal medicine; Cardiology; Medical physics; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02031584,0.001092872,0.004290756,0.00235384,0.000337509,0.003277706,0.002282417,0.003471387,0.006956647],"category_scores_gemma":[0.03668626,0.0005481732,0.002090937,0.002535657,0.001088011,0.002465715,0.001551656,0.004338739,0.001912197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001519574,"about_ca_system_score_gemma":0.003994918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006133547,"about_ca_topic_score_gemma":0.0009594341,"domain_scores_codex":[0.9912787,0.005206242,0.001315259,0.0004837383,0.001526005,0.0001899785],"domain_scores_gemma":[0.9599517,0.03328794,0.002659098,0.0006041243,0.002933022,0.0005641116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006095325,0.0001030634,0.0003472507,0.05645049,0.0006986986,0.0001459191,0.0001033219,0.0006917977,0.0004588242,0.01147673,0.04023148,0.888683],"study_design_scores_gemma":[0.0005543472,0.0005176752,0.001329468,0.08187273,0.001211827,0.0008336853,0.000104935,0.0004987134,0.0005996804,0.01545994,0.8969463,0.00007079016],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007205672,0.9970827,0.0004246713,0.0009895581,0.0004691913,0.00005132785,0.00004284588,0.00001137104,0.0008562804],"genre_scores_gemma":[0.0025751,0.9917015,0.001891147,0.002143818,0.0007620466,0.0002684507,0.0001404771,0.0000112386,0.0005061235],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02031584,"threshold_uncertainty_score":0.1074417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1832122974324876,"score_gpt":0.5053536385675799,"score_spread":0.3221413411350923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}