{"id":"W4406050225","doi":"10.2139/ssrn.5070097","title":"Anti-Cancer Potential of a New Derivative of Caffeic Acid Phenethyl Ester Targeting the Centrosome","year":2025,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Moncton","funders":"","keywords":"Downregulation and upregulation; Cancer research; Caffeic acid phenethyl ester; Programmed cell death; Apoptosis; Cancer; Chemistry; Leukemia; Caffeic acid; Biology; Immunology; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007867259,0.0002528172,0.0001966941,0.0002061972,0.0001236864,0.0001067291,0.0002018182,0.0002298378,0.001320345],"category_scores_gemma":[0.00007861371,0.00005864319,0.0001956635,0.0001186408,0.0001363783,0.0002049551,0.0001239421,0.0003207924,0.0002082795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001215331,"about_ca_system_score_gemma":0.0001371226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005352295,"about_ca_topic_score_gemma":0.0008341665,"domain_scores_codex":[0.9999753,0.000003338423,0.000001412786,0.000007030006,0.000004980539,0.000007898901],"domain_scores_gemma":[0.9999684,0.00000418395,0.000008264653,0.000003839295,0.000005007829,0.00001032541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002275038,0.0000240904,0.00006073851,0.00007714752,0.00001055912,0.00009299398,0.00001064398,0.0001134419,0.995699,0.0001216041,0.00006015881,0.003502127],"study_design_scores_gemma":[0.00005904559,0.0009924863,0.001046971,0.000004806944,0.00003862774,0.0002827601,0.000008539731,0.0002819281,0.9926932,0.00004743152,0.004538141,0.000006147213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986259,0.00656882,0.003143135,0.000236962,0.00007274192,0.00004925135,0.0002265389,0.00008924171,0.003354364],"genre_scores_gemma":[0.9938147,0.002249005,0.001436105,0.00005805831,0.00002360498,0.00001070276,0.0001683408,0.0000101454,0.002229464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320345,"threshold_uncertainty_score":0.004416943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009292739210578773,"score_gpt":0.2597182395221959,"score_spread":0.2504255003116171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}