{"id":"W4406050322","doi":"10.1002/alz.088478","title":"Whole Genome Sequencing Analysis of Cognitively Wellderly Individuals Identifies Potential Protective Genetic Variants for Alzheimer’s Disease","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Dementia; Apolipoprotein E; Allele; Locus (genetics); Genetics; Genetic association; Disease; Odds ratio; Minor allele frequency; Genome-wide association study; Alzheimer's disease; Gene; Single-nucleotide polymorphism; Allele frequency; Medicine; Biology; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006620176,0.0003655592,0.0003132185,0.0009408726,0.0003712906,0.000439719,0.0002391554,0.0003242166,0.001713597],"category_scores_gemma":[0.001105716,0.000137002,0.0004846167,0.0009179604,0.0002083292,0.0001657038,0.0002933633,0.0002338951,0.000205722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001370378,"about_ca_system_score_gemma":0.0001384249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004522788,"about_ca_topic_score_gemma":0.008396402,"domain_scores_codex":[0.9996514,0.00009628957,0.00003573945,0.00013019,0.00003528418,0.00005107409],"domain_scores_gemma":[0.9993302,0.0001678012,0.0002349372,0.0001148411,0.00008451329,0.00006783403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006223465,0.00007498285,0.9539136,0.00004652613,0.000448085,0.0005400853,0.0003504955,0.0003992616,0.03546306,0.0002969217,0.0005419603,0.007302795],"study_design_scores_gemma":[0.00001667492,0.0001007038,0.9950922,0.000008180497,0.000126977,0.0004395749,0.0001232483,0.0006630762,0.00238467,0.0002032215,0.000834605,0.000006779614],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997894,0.0001239237,0.0007681908,0.00002475606,0.00000343625,0.000006494573,0.000881856,0.00000926115,0.0002880642],"genre_scores_gemma":[0.9972596,0.00008411007,0.0009496982,0.00005641823,0.000006389058,0.00001005592,0.001184423,0.000008074438,0.0004410385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004522788,"threshold_uncertainty_score":0.00899297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02148568831466918,"score_gpt":0.2700632345449821,"score_spread":0.2485775462303129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}