{"id":"W4406050397","doi":"10.1002/alz.088220","title":"Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Proteasome; Hippocampal formation; Synaptic plasticity; Neuroscience; Biology; Long-term potentiation; Cell biology; Lactacystin; Neurodegeneration; Synapse; Genetically modified mouse; Hippocampus; Dendritic spine; Proteasome inhibitor; Chemistry; Transgene; Biochemistry; Internal medicine; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003002695,0.001635665,0.0006581302,0.0015064,0.0004651751,0.000616281,0.0005636874,0.0009449926,0.002276684],"category_scores_gemma":[0.0001675223,0.0005637967,0.0008494467,0.0004958438,0.0006041641,0.000472159,0.0003416341,0.001368971,0.001017391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005585925,"about_ca_system_score_gemma":0.0003485974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006353211,"about_ca_topic_score_gemma":0.0009533078,"domain_scores_codex":[0.999688,0.00002862379,0.00004391813,0.0001086335,0.00006452476,0.00006632281],"domain_scores_gemma":[0.9996313,0.0000215104,0.0001937333,0.00003115475,0.00003031808,0.00009196149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007161352,0.0003311025,0.001023015,0.000117085,0.00007126225,0.0004217954,0.00003322411,0.0000742893,0.9939303,0.0001775461,0.0002394176,0.002864869],"study_design_scores_gemma":[0.0002548346,0.002368363,0.03313141,0.00008761913,0.000289576,0.004294232,0.00009582381,0.001198468,0.9516666,0.0004869236,0.006101089,0.00002510825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836788,0.005652579,0.004682268,0.0004137474,0.0001065484,0.0001092418,0.002051439,0.0004849472,0.002820449],"genre_scores_gemma":[0.984797,0.003531514,0.003790283,0.0002374724,0.00004534878,0.0002552634,0.002214435,0.0001297888,0.004998881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002276684,"threshold_uncertainty_score":0.007616282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01862504321237528,"score_gpt":0.2508853085606482,"score_spread":0.2322602653482729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}