{"id":"W4406051255","doi":"10.1002/alz.090912","title":"Alzheimer’s disease multiomic signatures mediated by Cholesterol Ester Transfer Protein","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cholesterylester transfer protein; Apolipoprotein E; Biology; Genome-wide association study; Genetics; Transcriptome; Gene; Disease; Computational biology; Cholesterol; Gene expression; Medicine; Internal medicine; Endocrinology; Genotype; Single-nucleotide polymorphism; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001716422,0.0003203215,0.000272555,0.001394678,0.000351754,0.0004793836,0.0001821489,0.0001920009,0.002177134],"category_scores_gemma":[0.0003521357,0.0001242204,0.0005735928,0.00128657,0.0001636244,0.0003127994,0.0005156813,0.0002562433,0.0003507451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004332545,"about_ca_system_score_gemma":0.0003916544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002647253,"about_ca_topic_score_gemma":0.002951493,"domain_scores_codex":[0.9998685,0.00001644483,0.000008442195,0.00004822623,0.00003067375,0.00002774131],"domain_scores_gemma":[0.9997955,0.00003861317,0.00009363134,0.00001224078,0.00002830374,0.00003169125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002609408,0.000343833,0.4471188,0.001904877,0.001529885,0.002699171,0.0007754095,0.02967711,0.3910312,0.01108607,0.01182833,0.09939587],"study_design_scores_gemma":[0.0000658939,0.0004270869,0.8240848,0.0001605877,0.001124972,0.002579197,0.0004039898,0.08713946,0.03921935,0.01796038,0.02675959,0.0000747361],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9643154,0.001532016,0.01308963,0.0003043913,0.0000276562,0.0000640437,0.01509902,0.0006326797,0.004935053],"genre_scores_gemma":[0.9692901,0.0013694,0.01239102,0.00008782279,0.00001651665,0.0001210215,0.01400706,0.00006166525,0.002655386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002647253,"threshold_uncertainty_score":0.00728327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02474936284815932,"score_gpt":0.300546035367594,"score_spread":0.2757966725194347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}