{"id":"W4406051290","doi":"10.1083/jcb.202407068","title":"MYO18B promotes lysosomal exocytosis by facilitating focal adhesion maturation","year":2024,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Glycomics Network; Jiangnan University; Takeda Science Foundation; Beihang University; Japan Society for the Promotion of Science; Helsingin Yliopisto; Ministry of Education, Culture, Sports, Science and Technology; National Natural Science Foundation of China","keywords":"Exocytosis; Focal adhesion; Cell biology; Extracellular matrix; Lysosome; Actin; PTK2; Actin cytoskeleton; Extracellular; Endocytosis; Adhesion; Chemistry; Cell adhesion; Secretion; Biology; Cytoskeleton; Biochemistry; Cell; Signal transduction; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001049476,0.0002069828,0.0002002656,0.0001504515,0.0001396102,0.0002370874,0.0001375289,0.0001948224,0.001316554],"category_scores_gemma":[0.00006153248,0.00009718758,0.0001760773,0.00008414203,0.0001351161,0.0001237902,0.000238199,0.0003130166,0.0003842653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002079237,"about_ca_system_score_gemma":0.0001475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003830633,"about_ca_topic_score_gemma":0.0008038596,"domain_scores_codex":[0.9999269,0.00001000344,0.000006492629,0.00001335945,0.00001839718,0.00002494625],"domain_scores_gemma":[0.999946,0.000005300307,0.00001690714,0.000004446083,0.000005363573,0.00002195507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007708057,0.00001194825,0.0001899823,0.00003220233,0.000003357478,0.00005254273,0.000005543412,0.00002181734,0.998662,0.000076877,0.00005386318,0.0008128139],"study_design_scores_gemma":[0.0000326444,0.0002417518,0.01237914,0.00001113291,0.00001149111,0.0003571289,0.00003945981,0.0008237018,0.9794081,0.0000686432,0.006622211,0.000004628008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928008,0.002681789,0.002271606,0.0002083586,0.00003680168,0.00002199059,0.0003334704,0.00006482804,0.001580377],"genre_scores_gemma":[0.9937516,0.001403384,0.001738312,0.00009163322,0.00001322635,0.00003533685,0.0004314601,0.00002220292,0.002512746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001316554,"threshold_uncertainty_score":0.004404306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009004971795930525,"score_gpt":0.2328967865428608,"score_spread":0.2238918147469303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}