{"id":"W4406051416","doi":"10.7554/elife.101938.1","title":"Identifying Genetic Variations in emm89 Streptococcus pyogenes Linked to Severe Invasive Infections","year":2025,"lang":"en","type":"preprint","venue":"eLife","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Cybermedia Center, Osaka University; Japan Society for the Promotion of Science; Iwadare Scholarship Foundation; Research Organization of Information and Systems; Japan Agency for Medical Research and Development","keywords":"Streptococcus pyogenes; STREPTOCOCCAL INFECTIONS; Microbiology; Biology; Medicine; Genetics; Staphylococcus aureus; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002915904,0.0003926172,0.0003044699,0.0005171081,0.0002047389,0.0003006379,0.0001732417,0.0002892251,0.002219856],"category_scores_gemma":[0.0005330741,0.0001182595,0.000344377,0.0006396689,0.0002437271,0.00007907038,0.0003992601,0.0003224894,0.0002720119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001322128,"about_ca_system_score_gemma":0.0002219719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00234108,"about_ca_topic_score_gemma":0.002318964,"domain_scores_codex":[0.9998581,0.00002607141,0.00001409522,0.00004750251,0.00003007207,0.00002413091],"domain_scores_gemma":[0.9997405,0.00005763231,0.00009846398,0.00002234649,0.00002920786,0.0000517843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001235463,0.0001223403,0.8436993,0.0002096108,0.0003111329,0.00226081,0.000465874,0.0009195415,0.1222744,0.0004447857,0.001752461,0.02630422],"study_design_scores_gemma":[0.00002867098,0.0001553748,0.9808343,0.00003437185,0.0001749553,0.002158098,0.0002523791,0.0008513979,0.01162512,0.0002759754,0.00359746,0.00001190913],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969615,0.0002788604,0.0009860146,0.00007848272,0.00001012532,0.000009734623,0.001028709,0.0000202472,0.0006263667],"genre_scores_gemma":[0.9963916,0.0001912868,0.001430479,0.00005607434,0.0000139232,0.000008612007,0.001326181,0.00001190045,0.0005699887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00234108,"threshold_uncertainty_score":0.007426143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04437407596068894,"score_gpt":0.3512782539716208,"score_spread":0.3069041780109318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}