{"id":"W4406057636","doi":"10.1016/j.jns.2024.123379","title":"Diagnosing progressive multifocal leukoencephalopathy: Positive predictive value of CSF JC virus quantitative PCR and importance of recognizing suggestive neuroimaging findings","year":2025,"lang":"en","type":"article","venue":"Journal of the Neurological Sciences","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Public Health Agency of Canada; Western University","funders":"","keywords":"Progressive multifocal leukoencephalopathy; Neuroimaging; Predictive value; JC virus; Leukoencephalopathy; Medicine; Pathology; Virus; Virology; Internal medicine; Psychiatry; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001859805,0.0005006049,0.0004428318,0.00130644,0.0002935234,0.0008636576,0.0004908132,0.0008647759,0.001129623],"category_scores_gemma":[0.01720882,0.0002815408,0.0002379368,0.0003412798,0.0008180057,0.001039094,0.0004682357,0.0006932017,0.00043701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000231208,"about_ca_system_score_gemma":0.0004285876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009779931,"about_ca_topic_score_gemma":0.0009663242,"domain_scores_codex":[0.9985876,0.0004458259,0.000217681,0.000193025,0.0004048049,0.0001509567],"domain_scores_gemma":[0.991437,0.005978297,0.001082544,0.0001845868,0.0008615539,0.0004560814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002545277,0.00003561841,0.9744672,0.00008724084,0.0000320183,0.005213467,0.0001964631,0.0004492361,0.005490331,0.00004784331,0.0003307943,0.01339523],"study_design_scores_gemma":[0.00008614363,0.001125895,0.8246754,0.0003757628,0.0001947645,0.1356097,0.002081504,0.01559557,0.01761297,0.0005171066,0.002073897,0.00005120667],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939597,0.002058489,0.001560678,0.0003993283,0.0000539934,0.00002952447,0.00008249562,0.0000487104,0.001807062],"genre_scores_gemma":[0.9988195,0.0002944722,0.0006603115,0.00006688792,0.00004331622,0.000004482331,0.00003956973,0.000003883369,0.00006749306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001859805,"threshold_uncertainty_score":0.00983566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02380994646103094,"score_gpt":0.3165099798072344,"score_spread":0.2927000333462035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}