{"id":"W4406062882","doi":"10.1016/j.cellsig.2025.111588","title":"Pharmacological characterization of cannabidiol as a negative allosteric modulator of the 5-HT2A receptor","year":2025,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Montreal Neurological Institute and Hospital; Institut National de la Recherche Scientifique; McGill University","funders":"Fonds de Recherche du Québec - Santé; Mitacs; Canadian Institutes of Health Research; Université Laval","keywords":"Cannabidiol; Allosteric regulation; Allosteric modulator; Pharmacology; Chemistry; Receptor; Neuroscience; Biology; Biochemistry; Medicine; Cannabis; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002681539,0.0001250398,0.0003219295,0.0001117574,0.00006894168,0.000009768514,0.0001869156,0.0001030947,0.0005068728],"category_scores_gemma":[0.0001449579,0.00008608377,0.000186407,0.0005651311,0.0001694297,0.00003850619,0.0001064338,0.0002290607,0.000006355622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007703982,"about_ca_system_score_gemma":0.00037144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004645006,"about_ca_topic_score_gemma":8.265699e-7,"domain_scores_codex":[0.9987348,0.0001189822,0.0003734013,0.0002226769,0.0003440079,0.000206104],"domain_scores_gemma":[0.999195,0.00001851913,0.0001620203,0.0002035707,0.0003444303,0.00007646492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002402405,0.0001403089,0.001112427,0.000214347,0.000111206,0.000004371667,0.0002669343,0.00003629067,0.9955705,0.0002461908,0.0006708709,0.001386341],"study_design_scores_gemma":[0.0007460223,0.0001714143,0.005745804,0.0002290185,0.0001066202,0.000001988009,0.0001069631,0.001577917,0.9866558,0.00007902833,0.004506283,0.00007308566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941102,0.0002446167,0.001126055,0.002730348,0.0002280041,0.0007185858,0.00001534238,0.00001560327,0.0008112693],"genre_scores_gemma":[0.9886774,0.00005223517,0.00006374323,0.0002953207,0.00008365312,0.00004240896,0.00002026138,0.00001337829,0.01075158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009940308,"threshold_uncertainty_score":0.5549902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0142340719459179,"score_gpt":0.282443272740622,"score_spread":0.2682092007947041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}