{"id":"W4406065091","doi":"10.1007/s40744-024-00731-9","title":"Evaluation of Safety and Efficacy of a Single Lorecivivint Injection in Patients with Knee Osteoarthritis: A Multicenter, Observational Extension Trial","year":2025,"lang":"en","type":"article","venue":"Rheumatology and Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Observational study; Post-hoc analysis; Osteoarthritis; Adverse effect; Incidence (geometry); Placebo; WOMAC; Physical therapy; Internal medicine; Clinical trial; Alternative medicine; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002774301,0.00008076562,0.000290099,0.0001268313,0.00002826238,0.000002271561,0.00001175231,0.00008074577,0.00001394583],"category_scores_gemma":[0.0001023316,0.00006417061,0.0000213445,0.000102483,0.00007268256,0.00005106303,0.000009347267,0.00004800912,1.631911e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002229607,"about_ca_system_score_gemma":0.00006813739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000248712,"about_ca_topic_score_gemma":0.00006058691,"domain_scores_codex":[0.9992179,0.000117411,0.000269528,0.000151382,0.0001682553,0.00007555141],"domain_scores_gemma":[0.999463,0.0001110028,0.0001049516,0.0000852629,0.0002173263,0.00001851424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1118334,0.001503469,0.3616344,0.00003918152,0.00008703494,8.218062e-7,0.0004314286,0.000004771941,0.001674429,0.0006946742,0.000001394412,0.522095],"study_design_scores_gemma":[0.3503751,0.01352752,0.6322757,0.0008070443,0.00009711407,0.000008379229,0.0000814094,0.0001267636,0.002148456,0.0004689949,0.00002065401,0.00006290225],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968627,0.001689804,0.0000302799,0.00005127228,0.0001274965,0.001161534,0.000004179444,0.000007109516,0.0000655942],"genre_scores_gemma":[0.9995075,0.0002258094,0.0001626206,0.00002102328,0.00000273,0.0000255947,0.00004079482,0.000004664289,0.000009291871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5220321,"threshold_uncertainty_score":0.2616802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02623296896397935,"score_gpt":0.2799841190166003,"score_spread":0.2537511500526209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}