{"id":"W4406073136","doi":"10.1007/s10456-024-09966-0","title":"Ref-1 is overexpressed in neovascular eye disease and targetable with a novel inhibitor","year":2025,"lang":"en","type":"article","venue":"Angiogenesis","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canada Foundation for Innovation; School of Medicine, Indiana University; National Eye Institute; Riley Children's Foundation; National Heart, Lung, and Blood Institute; Research to Prevent Blindness","keywords":"Choroidal neovascularization; Macular degeneration; Angiogenesis; Neovascularization; Cancer research; Medicine; Inflammation; Ophthalmology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003790447,0.0003507274,0.0003816612,0.0003780449,0.0002742828,0.0003402695,0.0003518313,0.0004675089,0.003164348],"category_scores_gemma":[0.0002887008,0.0001706297,0.0004696175,0.0002369529,0.000274479,0.0002902951,0.0001671146,0.0008586866,0.0006895922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004921127,"about_ca_system_score_gemma":0.0003555715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006121787,"about_ca_topic_score_gemma":0.001016733,"domain_scores_codex":[0.9997653,0.00003195429,0.00001666336,0.0000359082,0.00006450655,0.00008560386],"domain_scores_gemma":[0.9998941,0.00002183127,0.00003296851,0.00001142722,0.00001433681,0.00002529932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001767602,0.0003578272,0.001960248,0.0001801264,0.00008767617,0.000889743,0.00003165609,0.0002817782,0.9797052,0.0008258536,0.001740471,0.01217174],"study_design_scores_gemma":[0.001289556,0.003698379,0.02280836,0.00005847287,0.0002702139,0.007907642,0.0001166039,0.00396266,0.923228,0.0006311831,0.03599054,0.00003846256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754444,0.01347187,0.002801241,0.001040507,0.0004475969,0.0000857607,0.000712855,0.0001928128,0.005803029],"genre_scores_gemma":[0.9901909,0.002669236,0.002368076,0.0003325381,0.0001166521,0.00005423836,0.001341589,0.00001956516,0.002907378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003164348,"threshold_uncertainty_score":0.01058578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00693087746435335,"score_gpt":0.2505671102200573,"score_spread":0.243636232755704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}