{"id":"W4406080800","doi":"10.1016/j.jcmgh.2024.101447","title":"Tofacitinib Mitigates the Increased SARS-CoV-2 Infection Susceptibility Caused by an IBD Risk Variant in the PTPN2 Gene","year":2025,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; University of California, Riverside; National Science Foundation; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Medicine; Immunology; Inflammatory bowel disease; Disease; Pandemic; Tofacitinib; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Rheumatoid arthritis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001828663,0.000345758,0.0004541514,0.0001521982,0.0001426217,0.0002793614,0.0001710748,0.0003855549,0.001540765],"category_scores_gemma":[0.0002159082,0.00008034058,0.0002225946,0.00009489869,0.0001317313,0.000145115,0.0001093437,0.0007026212,0.0001386774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001591852,"about_ca_system_score_gemma":0.0001595517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002880138,"about_ca_topic_score_gemma":0.0005686404,"domain_scores_codex":[0.9999254,0.00001614612,0.000005064956,0.00001448302,0.00001353249,0.00002540499],"domain_scores_gemma":[0.9999102,0.00001280576,0.00002817827,0.000005538902,0.0000093338,0.00003403217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02419409,0.003162522,0.01153438,0.0003551815,0.0003899604,0.0008877821,0.00006115722,0.0007814443,0.8947313,0.0001866317,0.001181252,0.06253432],"study_design_scores_gemma":[0.01677615,0.127744,0.3714597,0.0001640026,0.001603247,0.01137095,0.0004590754,0.008863976,0.4362783,0.000811967,0.02439087,0.00007773066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974827,0.001184855,0.0003069575,0.0001328888,0.00004465316,0.00002782066,0.0001182557,0.00004931873,0.0006525089],"genre_scores_gemma":[0.9982462,0.0004671295,0.0003505256,0.0001645946,0.00002779913,0.00002332751,0.0002613601,0.000005851996,0.0004531929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001540765,"threshold_uncertainty_score":0.005154312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006641399341498909,"score_gpt":0.2383599443621499,"score_spread":0.231718545020651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}