{"id":"W4406080800","doi":"10.1016/j.jcmgh.2024.101447","title":"Tofacitinib Mitigates the Increased SARS-CoV-2 Infection Susceptibility Caused by an IBD Risk Variant in the PTPN2 Gene","year":2025,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; University of California, Riverside; National Science Foundation; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Medicine; Immunology; Inflammatory bowel disease; Disease; Pandemic; Tofacitinib; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Rheumatoid arthritis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006555572,0.000250262,0.0002736851,0.00006292755,0.000226981,0.00003731778,0.0002347732,0.000259681,0.000003784599],"category_scores_gemma":[0.0001291473,0.0001816985,0.0000724845,0.00009051861,0.0006060144,0.000009394687,0.0001762023,0.0002919388,8.860957e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000984854,"about_ca_system_score_gemma":0.00004328901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001078847,"about_ca_topic_score_gemma":0.002028423,"domain_scores_codex":[0.9974645,0.001180898,0.0002942939,0.0005892518,0.00006867021,0.0004024066],"domain_scores_gemma":[0.999222,0.00004099659,0.0001050173,0.0005392961,0.00004412928,0.00004860362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000357349,0.0001405961,0.3132128,0.00002132859,0.00009403747,0.00007022569,0.00005717081,0.000002842161,0.6843317,0.0007410368,0.000647067,0.000323896],"study_design_scores_gemma":[0.001892179,0.000855396,0.03957047,0.000008041789,0.0001392572,0.0001991582,0.000046803,0.0002636255,0.9515748,0.001175778,0.004116905,0.0001576028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830472,0.004671604,0.01064368,0.0009379778,0.00008866215,0.0004599702,0.0001101498,0.0000132773,0.00002748071],"genre_scores_gemma":[0.993812,0.0006639245,0.0001067622,0.004749347,0.00002391956,0.0001030647,0.0005234341,0.00001299631,0.000004615978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2736423,"threshold_uncertainty_score":0.7409449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006641399341498909,"score_gpt":0.2383599443621499,"score_spread":0.231718545020651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}