{"id":"W4406100666","doi":"10.3390/genes16010052","title":"Heart Morphogenesis Requires Smyd1b for Proper Incorporation of the Second Heart Field in Zebrafish","year":2025,"lang":"en","type":"article","venue":"Genes","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"MacEwan University; University of Guelph; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; University of Alberta","keywords":"Zebrafish; Heart development; Biology; GATA4; Cell biology; Morphogenesis; Transcription factor; Genetic screen; Heart failure; TBX1; GATA6; Mutant; Gene; Gene expression; Genetics; Internal medicine; Medicine; Embryonic stem cell; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001369214,0.0004557553,0.000230309,0.0004670479,0.0003623043,0.0002189808,0.0002960313,0.0004922009,0.002157911],"category_scores_gemma":[0.00009563562,0.000367835,0.0003298818,0.00009948933,0.0003696837,0.0002634148,0.0004412895,0.0006823673,0.0006629062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008469191,"about_ca_system_score_gemma":0.0004938657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004239954,"about_ca_topic_score_gemma":0.00671316,"domain_scores_codex":[0.9998893,0.000005772195,0.000007812685,0.00003478709,0.00003747518,0.00002493679],"domain_scores_gemma":[0.9998617,0.00001099505,0.00005567313,0.000007765329,0.00001686303,0.00004704087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003299617,0.000002673445,0.0001664336,0.00002599926,0.00000126879,0.00005689418,0.00001290693,0.00004084991,0.9989452,0.0001296964,0.0000406523,0.0005444443],"study_design_scores_gemma":[0.00005889526,0.0002100828,0.03155694,0.0000457489,0.00003227804,0.0006015992,0.00008155397,0.002561295,0.9565474,0.0001892406,0.008095648,0.00001942756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782509,0.002604069,0.01137977,0.0003495321,0.00005815327,0.0000528,0.001369905,0.0002940805,0.005640748],"genre_scores_gemma":[0.977222,0.0009589767,0.008602166,0.0001582507,0.00001103851,0.0001018136,0.0007162631,0.0001724217,0.01205684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004239954,"threshold_uncertainty_score":0.008430541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369218165089795,"score_gpt":0.2930208573122289,"score_spread":0.279328675661331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}