{"id":"W4406101478","doi":"10.3390/ijms26010421","title":"Single and Combined Impact of Semaglutide, Tirzepatide, and Metformin on β-Cell Maintenance and Function Under High-Glucose–High-Lipid Conditions: A Comparative Study","year":2025,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Mitacs","keywords":"Semaglutide; Metformin; Medicine; Function (biology); Internal medicine; Chemistry; Endocrinology; Pharmacology; Diabetes mellitus; Type 2 diabetes; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002686498,0.0004352572,0.00112923,0.0004330381,0.0001905637,0.0004140996,0.0003825216,0.0003993081,0.001060871],"category_scores_gemma":[0.0001457454,0.0001710606,0.0007849677,0.0003962547,0.0002177767,0.0004605159,0.0002549559,0.0007757887,0.0001838256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002102232,"about_ca_system_score_gemma":0.0003196144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004704379,"about_ca_topic_score_gemma":0.0009086451,"domain_scores_codex":[0.9998044,0.00004151247,0.00002447286,0.00003950546,0.00003977057,0.00005033443],"domain_scores_gemma":[0.9998816,0.00001811842,0.00001976861,0.00001461284,0.00001635247,0.00004949866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01606422,0.003866092,0.001377831,0.0005871619,0.0002627119,0.0002622081,0.00009345108,0.000407638,0.9559701,0.0001102301,0.0002462874,0.02075202],"study_design_scores_gemma":[0.001419765,0.09034865,0.03492821,0.00004995209,0.001355561,0.0008795899,0.0003876087,0.00185049,0.8612654,0.0001038246,0.007346422,0.00006463029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958093,0.003229264,0.0001793192,0.00004357402,0.00005036543,0.00003264801,0.0001110076,0.00001045842,0.0005340164],"genre_scores_gemma":[0.9935172,0.003861092,0.001112876,0.00006687443,0.00005888307,0.00006746325,0.0003180971,0.000008215939,0.0009894769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00112923,"threshold_uncertainty_score":0.00354898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0199238990302086,"score_gpt":0.319005243469991,"score_spread":0.2990813444397824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}