{"id":"W4406104610","doi":"10.22541/au.173621928.86704200/v1","title":"Novel drugs approved by the EMA, the FDA and the MHRA in 2024: a year in review","year":2025,"lang":"en","type":"preprint","venue":"","topic":"Science, Research, and Medicine","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006117225,0.0002107822,0.0006338947,0.0001215487,0.00007037825,0.00003749846,0.0006709947,0.0001261041,0.0002564352],"category_scores_gemma":[0.001566169,0.00007251809,0.0001043031,0.0006792186,0.0008013138,0.00002195859,0.000764868,0.001601917,0.00001288203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007037314,"about_ca_system_score_gemma":0.0005764588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004757362,"about_ca_topic_score_gemma":0.0007162244,"domain_scores_codex":[0.9977977,0.0002342994,0.0004422426,0.0004713772,0.0007030868,0.0003512425],"domain_scores_gemma":[0.9978838,0.0008414938,0.00008608514,0.001006846,0.00008891724,0.00009284748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008156896,0.0005770571,0.004466715,0.01195863,0.0002475056,0.00003795308,0.01892764,0.000006090416,0.0004638835,0.01333437,0.8213348,0.1278297],"study_design_scores_gemma":[0.02512731,0.0002450671,0.02294241,0.04974415,0.0007790115,0.0001232502,0.03134225,0.006814295,0.0002047315,0.00395555,0.8579174,0.00080463],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.01376186,0.1728477,0.0002661509,0.4463053,0.000815703,0.01017815,0.00003655229,0.00004306547,0.3557455],"genre_scores_gemma":[0.1020198,0.37962,0.0004796929,0.104382,0.0007273089,0.002129216,0.00007258662,0.0000493775,0.41052],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.3419232,"threshold_uncertainty_score":0.7191741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03261198715470274,"score_gpt":0.3600699886775348,"score_spread":0.327458001522832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}