{"id":"W4406109428","doi":"10.1093/brain/awaf003","title":"Plasma pTau181 and amyloid markers predict conversion to dementia in idiopathic REM sleep behaviour disorder","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; McGill Genome Centre; Hôpital du Sacré-Cœur de Montréal; McGill University Health Centre; McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Idorsia Pharmaceuticals; Fonds de Recherche du Québec - Santé; Norges Idrettshøgskole; National Institutes of Health; Canada First Research Excellence Fund; Eisai; Jazz Pharmaceuticals; McGill University; Consortium canadien en neurodégénérescence associée au vieillissement; F. Hoffmann-La Roche; Roche; Bristol-Myers Squibb; Eli Lilly and Company; Biogen; Michael J. Fox Foundation for Parkinson's Research","keywords":"Dementia; REM sleep behavior disorder; Medicine; Amyloid (mycology); Sleep (system call); Psychology; Neuroscience; Polysomnography; Internal medicine; Pathology; Disease; Electroencephalography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002089699,0.0001492219,0.0002224596,0.0002159826,0.00006224823,0.00001654519,0.00005595681,0.00008256514,0.00008845107],"category_scores_gemma":[0.00008703629,0.0001377927,0.00004888267,0.0002291698,0.0000243081,0.00005024206,0.00008021513,0.0001000663,0.00002789073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007817895,"about_ca_system_score_gemma":0.00006644935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000142042,"about_ca_topic_score_gemma":0.0001144753,"domain_scores_codex":[0.9990178,0.00005645155,0.0001842811,0.0003381468,0.0001669588,0.0002363995],"domain_scores_gemma":[0.9995405,0.0000311019,0.00003175988,0.0001963658,0.00002219897,0.0001780696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007675058,0.0003716158,0.9765108,0.0001193448,0.0001376661,0.0002419533,0.0001490645,0.000004094962,0.001358771,0.0001639156,0.003250462,0.0169248],"study_design_scores_gemma":[0.005347045,0.0002942506,0.9813104,0.0003618989,0.0002276604,0.000009405474,0.0002431913,0.0008817546,0.0008798903,0.00009133091,0.01023199,0.0001211917],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948714,0.0008173507,0.0002623291,0.002157301,0.0001616042,0.0005758619,0.00002424039,0.00004462173,0.001085272],"genre_scores_gemma":[0.9972537,0.00004622542,0.0003463994,0.001048827,0.0000160245,0.00005632108,0.00002974904,0.00001428356,0.001188435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01680361,"threshold_uncertainty_score":0.5619022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006345432722323051,"score_gpt":0.2433919401603353,"score_spread":0.2370465074380122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}