{"id":"W4406109428","doi":"10.1093/brain/awaf003","title":"Plasma pTau181 and amyloid markers predict conversion to dementia in idiopathic REM sleep behaviour disorder","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; McGill Genome Centre; Hôpital du Sacré-Cœur de Montréal; McGill University Health Centre; McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Idorsia Pharmaceuticals; Fonds de Recherche du Québec - Santé; Norges Idrettshøgskole; National Institutes of Health; Canada First Research Excellence Fund; Eisai; Jazz Pharmaceuticals; McGill University; Consortium canadien en neurodégénérescence associée au vieillissement; F. Hoffmann-La Roche; Roche; Bristol-Myers Squibb; Eli Lilly and Company; Biogen; Michael J. Fox Foundation for Parkinson's Research","keywords":"Dementia; REM sleep behavior disorder; Medicine; Amyloid (mycology); Sleep (system call); Psychology; Neuroscience; Polysomnography; Internal medicine; Pathology; Disease; Electroencephalography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002577451,0.0004167711,0.0003768171,0.0005075284,0.0006282868,0.000612409,0.0003715721,0.0004866275,0.001171653],"category_scores_gemma":[0.001035022,0.0003838165,0.0002517099,0.0005014096,0.0002759037,0.000234764,0.000338687,0.000568399,0.0002896067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006859913,"about_ca_system_score_gemma":0.0005118159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.06249976,"about_ca_topic_score_gemma":0.09080492,"domain_scores_codex":[0.9998785,0.0000148031,0.00001282503,0.00003571335,0.00003147373,0.00002665037],"domain_scores_gemma":[0.9995598,0.00004950746,0.0001629485,0.00002945116,0.00007755353,0.0001206412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002160486,0.00003003632,0.9982267,0.000004303893,0.00001591559,0.0001382601,0.00006835886,0.00002279516,0.0005951339,0.000004409854,0.00003372404,0.0006443293],"study_design_scores_gemma":[0.000005904858,0.00005917941,0.9994822,0.000002107648,0.000007884878,0.000200426,0.0000593312,0.00009348468,0.00004505715,0.000006063261,0.00003710409,0.000001267354],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996446,0.0000826596,0.00001686836,0.000008470302,0.000001814036,0.000005970314,0.00008046261,0.000001582059,0.0001574886],"genre_scores_gemma":[0.9994181,0.00005539242,0.00005882053,0.00001223573,0.000002608708,0.000004298949,0.0002137552,8.926563e-7,0.0002339013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06249976,"threshold_uncertainty_score":0.1242719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006345432722323051,"score_gpt":0.2433919401603353,"score_spread":0.2370465074380122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}