{"id":"W4406114555","doi":"10.1101/2024.12.31.630809","title":"TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Diego; Connaught Fund; Children’s Hospital of Wisconsin Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Seattle Children's Research Institute; Ohio State University","keywords":"Biogenesis; Cell biology; Heat shock; Shock (circulatory); Peroxisome; Biology; Heat shock protein; Genetics; Medicine; Receptor; Internal medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001041967,0.000243305,0.0001945015,0.0001847167,0.0001911471,0.0003234312,0.00009888627,0.0002079555,0.001835204],"category_scores_gemma":[0.00007236833,0.00008825956,0.0001597572,0.0001484132,0.0002104528,0.0001340311,0.0002509926,0.0003391275,0.0006020705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002420934,"about_ca_system_score_gemma":0.0001578245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005546559,"about_ca_topic_score_gemma":0.0006341227,"domain_scores_codex":[0.9999356,0.000009348833,0.000004958513,0.00001226399,0.00001687737,0.00002082549],"domain_scores_gemma":[0.9999495,0.000006635821,0.00001530775,0.000007606889,0.000008193302,0.00001277862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002139416,0.000009998273,0.0002428649,0.00003759064,0.000003918025,0.00006913159,0.00001024141,0.00007583026,0.9979438,0.00013041,0.0001084724,0.001153877],"study_design_scores_gemma":[0.00001468113,0.0001061042,0.01602817,0.000008882171,0.000009933254,0.0002513374,0.00005999667,0.0007682701,0.9802828,0.0002154127,0.002247754,0.00000657804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985348,0.004048272,0.00474152,0.0003402758,0.00009264806,0.00004407034,0.001759402,0.0002662764,0.003359394],"genre_scores_gemma":[0.9913441,0.001092706,0.001464655,0.00008657861,0.00001358177,0.00003400752,0.001405749,0.00003884521,0.004519843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001835204,"threshold_uncertainty_score":0.006139338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007109047312789976,"score_gpt":0.2063905609302263,"score_spread":0.1992815136174363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}