{"id":"W4406115561","doi":"10.1002/adma.202419306","title":"Colloid‐Forming Prodrug‐Hydrogel Composite Prolongs Lower Intraocular Pressure in Rodent Eyes after Subconjunctival Injection","year":2025,"lang":"en","type":"article","venue":"Advanced Materials","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University Health Network; Toronto Rehabilitation Institute; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Krembil Foundation; Glaucoma Research Foundation","keywords":"Timolol; Prodrug; Pharmacology; Drug; Intraocular pressure; Drug delivery; Glaucoma; Systemic administration; In vivo; Ophthalmology; Chemistry; Medicine; Materials science; Nanotechnology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002895452,0.0002379926,0.0005075847,0.0001651114,0.00005784194,0.00004462739,0.0000805342,0.0001430257,0.0001109221],"category_scores_gemma":[0.00007342787,0.0002121116,0.00007602656,0.0002381427,0.00004042993,0.0002909194,0.00007586807,0.0001471998,0.00003016759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001316542,"about_ca_system_score_gemma":0.0001033964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001354334,"about_ca_topic_score_gemma":0.00008893267,"domain_scores_codex":[0.9985068,0.00005487512,0.0004260801,0.0004079939,0.0002505558,0.0003536502],"domain_scores_gemma":[0.9993341,0.00002007781,0.00009657273,0.0003553056,0.0001331293,0.00006084554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003034914,0.0002249465,0.03300129,0.0004433895,0.0001290349,0.0001050108,0.000224478,0.0001962904,0.9607567,0.000157802,0.00001774856,0.001708436],"study_design_scores_gemma":[0.002411243,0.000287311,0.03525872,0.0007299428,0.0001864987,0.00001161064,0.00007565429,0.00003436659,0.9520168,0.0003556506,0.008401661,0.0002305461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956222,0.0009753018,0.0001992898,0.0003489738,0.0009076318,0.001398019,0.00001599566,0.0001009062,0.000431746],"genre_scores_gemma":[0.9965209,0.00005778574,0.0006191249,0.0004949601,0.00007966681,0.0003063576,0.00002501589,0.00002938519,0.00186682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008739864,"threshold_uncertainty_score":0.8649659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003470372204005237,"score_gpt":0.2436233504537144,"score_spread":0.2401529782497092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}