{"id":"W4406119011","doi":"10.3390/cells14020072","title":"Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Garron Family Cancer Centre; National Institutes of Health; Genome Canada; Hospital de Clínicas de Porto Alegre; University of Toronto; Ministério da Ciência, Tecnologia e Inovação; Brain Tumour Charity; Cancer Research UK; Stand Up To Cancer; Hospital for Sick Children; Genome British Columbia; Government of Canada; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Government of Ontario; V Foundation for Cancer Research; Brain Tumour Foundation of Canada; Fondation Brain Canada; Swifty Foundation; Rally Foundation; Canadian Cancer Society Research Institute; Matthew Larson Foundation for Pediatric Brain Tumors; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Canadian Institutes of Health Research; Terry Fox Research Institute; Cancer Prevention and Research Institute of Texas; C.R. Younger Foundation; Pediatric Brain Tumor Foundation","keywords":"Neurosphere; Biology; Acetylation; Medulloblastoma; Histone; Epigenetics; Cancer research; Valproic Acid; Cellular differentiation; Histone deacetylase; Cell biology; Genetics; Epilepsy; Gene; Neuroscience; Adult stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008251559,0.00007362004,0.00009962996,0.00005205339,0.00002292724,0.000008821023,0.00006945244,0.00009340884,0.000009014054],"category_scores_gemma":[0.00002766888,0.00007593988,0.00002375878,0.0001058926,0.00005837595,0.000003247611,0.00005976226,0.00005057133,0.000001460435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001515718,"about_ca_system_score_gemma":0.00002780961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002389778,"about_ca_topic_score_gemma":0.00003418159,"domain_scores_codex":[0.9993631,0.00006420199,0.0001620869,0.0002060852,0.00009532609,0.0001092085],"domain_scores_gemma":[0.9997097,0.000008991577,0.00004396484,0.0001703193,0.00004040149,0.00002660236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003782467,0.00004079327,0.003331528,0.00005471125,0.000006732065,3.358602e-7,0.00002426134,0.00006485722,0.9930295,0.00001840108,0.00173063,0.001660463],"study_design_scores_gemma":[0.0003549985,0.00005235023,0.01586094,0.00002156432,0.000003384552,3.529605e-7,0.00002027339,0.0006786301,0.9821592,0.00003219241,0.0007581342,0.00005798935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984363,0.0005164418,0.0005349868,0.00003861,0.00009418016,0.000152921,0.000008421172,0.000004067212,0.000214038],"genre_scores_gemma":[0.9984509,0.00004473519,0.0000420174,0.00001405116,0.00001450188,0.000009979176,0.00003593264,0.000008102005,0.001379815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01252941,"threshold_uncertainty_score":0.3096738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003391114527177005,"score_gpt":0.2325541215915869,"score_spread":0.2291630070644099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}