{"id":"W4406119011","doi":"10.3390/cells14020072","title":"Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Garron Family Cancer Centre; National Institutes of Health; Genome Canada; Hospital de Clínicas de Porto Alegre; University of Toronto; Ministério da Ciência, Tecnologia e Inovação; Brain Tumour Charity; Cancer Research UK; Stand Up To Cancer; Hospital for Sick Children; Genome British Columbia; Government of Canada; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Government of Ontario; V Foundation for Cancer Research; Brain Tumour Foundation of Canada; Fondation Brain Canada; Swifty Foundation; Rally Foundation; Canadian Cancer Society Research Institute; Matthew Larson Foundation for Pediatric Brain Tumors; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Canadian Institutes of Health Research; Terry Fox Research Institute; Cancer Prevention and Research Institute of Texas; C.R. Younger Foundation; Pediatric Brain Tumor Foundation","keywords":"Neurosphere; Biology; Acetylation; Medulloblastoma; Histone; Epigenetics; Cancer research; Valproic Acid; Cellular differentiation; Histone deacetylase; Cell biology; Genetics; Epilepsy; Gene; Neuroscience; Adult stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006037332,0.0002125829,0.0001944303,0.0002215496,0.0001154088,0.0001818332,0.0001036855,0.0001096307,0.0003396369],"category_scores_gemma":[0.00005960374,0.00007157474,0.0001843775,0.0001157819,0.0001369376,0.0001356521,0.0001345762,0.0002244652,0.00009509391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003119715,"about_ca_system_score_gemma":0.0001835695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001581624,"about_ca_topic_score_gemma":0.001808976,"domain_scores_codex":[0.9999415,0.000009669325,0.000007208996,0.00001285491,0.00001860442,0.00001028114],"domain_scores_gemma":[0.9999635,0.000005942193,0.000009784369,0.00000470206,0.000004504036,0.00001152478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006601466,0.00000837734,0.0001583643,0.00001483558,0.000003852568,0.00003200149,0.000009306395,0.00003801786,0.9988978,0.00003129481,0.00001137096,0.0007288196],"study_design_scores_gemma":[0.000009112811,0.0001700914,0.006872164,0.000002728772,0.0000126728,0.0001450957,0.00002763895,0.0004743869,0.9908922,0.00003322144,0.001358278,0.000002420225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962004,0.001890523,0.000953554,0.00002794103,0.00001052365,0.00001526615,0.0003816699,0.0000417881,0.0004783937],"genre_scores_gemma":[0.9969715,0.0009006344,0.0009813654,0.00001349506,0.000003395864,0.00002024999,0.0004814096,0.000009607104,0.0006182085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001581624,"threshold_uncertainty_score":0.003144801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003391114527177005,"score_gpt":0.2325541215915869,"score_spread":0.2291630070644099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}