{"id":"W4406121076","doi":"10.1016/s2468-1253(24)00386-8","title":"Tamuzimod in patients with moderately-to-severely active ulcerative colitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 induction trial","year":2025,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; University of Calgary","funders":"Bristol-Myers Squibb","keywords":"Medicine; Ulcerative colitis; Placebo; Internal medicine; Adverse effect; Clinical endpoint; Nausea; Gastroenterology; Clinical trial; Randomized controlled trial; Intention-to-treat analysis; Surgery; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001198453,0.002038153,0.004031787,0.0003802936,0.000395089,0.001040072,0.0009810607,0.002051693,0.006779823],"category_scores_gemma":[0.001386272,0.0005802847,0.001591763,0.000386958,0.0009414191,0.001142637,0.0004663739,0.002617401,0.001239981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006246539,"about_ca_system_score_gemma":0.0006708778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006756866,"about_ca_topic_score_gemma":0.001390279,"domain_scores_codex":[0.9995582,0.0002088378,0.00002631962,0.00007626459,0.00003301484,0.00009744423],"domain_scores_gemma":[0.9995383,0.0001317567,0.00009966978,0.00003481776,0.00003347222,0.0001620972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9822842,0.002008472,0.000249534,0.0008415821,0.0006045594,0.00004370468,0.00003329734,0.0001495868,0.002629705,0.00007547071,0.0008326267,0.01024722],"study_design_scores_gemma":[0.9789396,0.01924138,0.0009886184,0.00002497449,0.0002051179,0.00002147276,0.00001242665,0.0001194032,0.0001270504,0.00005441733,0.0002574915,0.000008048032],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978203,0.0127191,0.0006902354,0.001354598,0.001193626,0.002288921,0.0009901295,0.0001962375,0.002364166],"genre_scores_gemma":[0.9818844,0.005680825,0.00152834,0.001870497,0.0007890094,0.002930177,0.001169633,0.00003263792,0.004114363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006779823,"threshold_uncertainty_score":0.02268076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134477913867359,"score_gpt":0.2743720394790709,"score_spread":0.2609242480923349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}