{"id":"W4406122186","doi":"10.1016/j.bbii.2025.100104","title":"Maternal social isolation during pre-conception and pregnancy programs inflammatory markers and biobehavioural aging trajectories in distant F4 offspring","year":2025,"lang":"en","type":"article","venue":"Brain Behavior and Immunity Integrative","topic":"Birth, Development, and Health","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates","keywords":"Offspring; Isolation (microbiology); Social isolation; Pregnancy; Biology; Developmental psychology; Medicine; Psychology; Genetics; Bioinformatics; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002013732,0.0001927866,0.0002731263,0.0001812977,0.0003336337,0.00007500539,0.0000385452,0.0001185285,0.000007065007],"category_scores_gemma":[0.00002931399,0.0001671927,0.00002924036,0.0001444555,0.0002837107,0.0002437786,0.00005922726,0.0004269535,1.497195e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001600969,"about_ca_system_score_gemma":0.0001001335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001255708,"about_ca_topic_score_gemma":0.001418121,"domain_scores_codex":[0.999004,0.0001171479,0.0003199826,0.000221837,0.000105985,0.0002310625],"domain_scores_gemma":[0.9996707,0.00002611724,0.00009336344,0.00008158128,0.00006380498,0.00006443376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001817614,0.00007751179,0.9312783,0.0002578726,0.00001494165,0.00001008543,0.02085982,1.407796e-8,0.01698749,0.001232325,0.00000254067,0.02909729],"study_design_scores_gemma":[0.001550891,0.00015039,0.9826919,0.001680477,0.00005254287,0.00001470503,0.01122202,0.00001807904,0.002233876,0.0002353935,0.000005473468,0.0001442042],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980686,0.0005565656,0.00006358208,0.0002434859,0.00008888705,0.0007946171,0.000007425107,0.00004511074,0.0001317404],"genre_scores_gemma":[0.9982244,0.001210414,0.0002495008,0.00002926209,0.00001816654,0.0001113171,0.00003352781,0.00001133093,0.0001120669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0514136,"threshold_uncertainty_score":0.6817921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01644852185878573,"score_gpt":0.3032880838803366,"score_spread":0.2868395620215508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}