{"id":"W4406131830","doi":"10.1101/2025.01.06.631556","title":"Psilocybin induces sex- and context-specific recruitment of the stress axis","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Calgary","funders":"Cumming School of Medicine, University of Calgary; Killam Trusts; Fondation Brain Canada; Hope for Depression Research Foundation","keywords":"Psilocybin; Context (archaeology); Psychology; Hallucinogen; Biology; Psychiatry; Paleontology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005032924,0.0005155108,0.0007296515,0.000197551,0.0002164005,0.00008404118,0.0007445934,0.0005005415,0.0000620084],"category_scores_gemma":[0.00006919295,0.0004221295,0.0001760374,0.0003827082,0.0003499012,0.00003704761,0.001027719,0.0007175938,0.00001470851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009579453,"about_ca_system_score_gemma":0.0002447452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002491133,"about_ca_topic_score_gemma":0.00001986221,"domain_scores_codex":[0.9973504,0.0002684986,0.0006448127,0.0009905566,0.0003053374,0.0004404255],"domain_scores_gemma":[0.9971966,0.0001656885,0.0004940519,0.0016789,0.0003490172,0.0001157549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"observational","study_design_scores_codex":[0.0006686587,0.004097828,0.2643744,0.00392076,0.009752657,0.0001222382,0.004114952,0.00004545245,0.2913616,0.3696012,0.05056695,0.001373239],"study_design_scores_gemma":[0.002199243,0.0001339705,0.7166045,0.002030997,0.0003847687,2.429404e-8,0.0004495281,0.00001550729,0.117933,0.00006889884,0.158719,0.001460559],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9632026,0.02841233,0.00006167858,0.0008165663,0.004295656,0.001487084,0.001062108,0.0001193073,0.0005426456],"genre_scores_gemma":[0.9972503,0.001399465,0.0001580393,0.0002520394,0.0002286088,0.0005325283,1.637097e-7,0.00004544708,0.0001334702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.45223,"threshold_uncertainty_score":0.999823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06082540112039351,"score_gpt":0.2981527407522055,"score_spread":0.237327339631812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}