{"id":"W4406135884","doi":"10.1098/rsob.240310","title":"Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide","year":2025,"lang":"en","type":"article","venue":"Open Biology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; Diamond Light Source; Fonds Wetenschappelijk Onderzoek; Canada Research Chairs; Wellcome Trust","keywords":"Flippase; Biology; Biogenesis; Lipid II; Escherichia coli; Bacterial outer membrane; Glycan; Biochemistry; Twin-arginine translocation pathway; Membrane protein; Biosynthesis; Membrane transport protein; Enzyme; Phospholipid; Membrane; Gene; Phosphatidylserine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007278899,0.0003504331,0.0003685524,0.0001561995,0.0002675384,0.000385017,0.0004180345,0.0005376919,0.001697789],"category_scores_gemma":[0.0001947106,0.0001823068,0.0002057459,0.0002619487,0.0002237519,0.0003570074,0.0002629712,0.0009008328,0.0004848785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004522139,"about_ca_system_score_gemma":0.0002977682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001966427,"about_ca_topic_score_gemma":0.001301081,"domain_scores_codex":[0.9999613,0.000005358828,0.000001801417,0.000008810543,0.00001363321,0.000009211295],"domain_scores_gemma":[0.9999201,0.00001376956,0.00002287677,0.000003510409,0.00001539816,0.00002433669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001007888,0.0002205151,0.005023832,0.0004553917,0.00006715344,0.0040499,0.0005278678,0.008201936,0.9566082,0.005050144,0.003104618,0.01568267],"study_design_scores_gemma":[0.0004108353,0.002531606,0.1299298,0.0002849988,0.0001896954,0.006489837,0.001921823,0.09947626,0.6774489,0.004200959,0.07683512,0.0002801883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885406,0.002218195,0.005479163,0.0003165255,0.00007342776,0.00003414588,0.0005727153,0.0001175494,0.002647691],"genre_scores_gemma":[0.9860005,0.001702753,0.004104658,0.000186734,0.0000220854,0.00001994158,0.002633238,0.00003636023,0.005293813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001966427,"threshold_uncertainty_score":0.005679607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464910603447093,"score_gpt":0.3492427419577798,"score_spread":0.3345936359233089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}