{"id":"W4406135884","doi":"10.1098/rsob.240310","title":"Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide","year":2025,"lang":"en","type":"article","venue":"Open Biology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; Diamond Light Source; Fonds Wetenschappelijk Onderzoek; Canada Research Chairs; Wellcome Trust","keywords":"Flippase; Biology; Biogenesis; Lipid II; Escherichia coli; Bacterial outer membrane; Glycan; Biochemistry; Twin-arginine translocation pathway; Membrane protein; Biosynthesis; Membrane transport protein; Enzyme; Phospholipid; Membrane; Gene; Phosphatidylserine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001926755,0.0001228535,0.0002444501,0.00002671222,0.0001471298,0.00002848109,0.0008131495,0.000140712,0.00003498295],"category_scores_gemma":[0.0001566324,0.00008109349,0.00007522973,0.00008309109,0.0002196544,0.000002990635,0.001038658,0.00007957895,7.436983e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008443704,"about_ca_system_score_gemma":0.000108713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002569058,"about_ca_topic_score_gemma":0.0006676752,"domain_scores_codex":[0.9991104,0.0001309093,0.0002078167,0.0002726954,0.00003516541,0.0002430056],"domain_scores_gemma":[0.9993272,0.0000556162,0.00008797564,0.0004036589,0.00009879262,0.00002676188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005842812,0.00002953584,0.008674906,0.00001536718,0.0001837862,1.731711e-7,0.00002961479,0.000001011214,0.9810592,0.001295578,0.006223253,0.001903304],"study_design_scores_gemma":[0.001452389,0.0005051552,0.006775803,0.00001360572,0.00002373547,0.000001891813,0.00009482335,0.00001488,0.7625237,0.0007955054,0.2276701,0.0001283663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959322,0.0004062657,0.0003169086,0.001107258,0.0003609147,0.0007778897,0.0002269314,0.000003719238,0.0008678677],"genre_scores_gemma":[0.9975351,0.0002474975,0.0004333422,0.0006246311,0.0002062214,0.00006536562,0.000173958,0.000008447702,0.0007054246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2214469,"threshold_uncertainty_score":0.3306897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464910603447093,"score_gpt":0.3492427419577798,"score_spread":0.3345936359233089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}