{"id":"W4406136889","doi":"10.1038/s41467-025-55843-9","title":"Safety and immunogenicity of an optimized self-replicating RNA platform for low dose or single dose vaccine applications: a randomized, open label Phase I study in healthy volunteers","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Cancer Institute; King Saud University","keywords":"Immunogenicity; Immunity; Immune system; Adverse effect; Medicine; Immunology; Virology; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001060038,0.0001704734,0.0004787052,0.0001164715,0.0002536323,0.00004998761,0.001389776,0.0002339628,0.000003068173],"category_scores_gemma":[0.0003662405,0.0001474736,0.00006774751,0.0003211069,0.0000779048,0.00002696639,0.000764574,0.0003005141,3.995598e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004783776,"about_ca_system_score_gemma":0.0002159233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001828735,"about_ca_topic_score_gemma":0.001806989,"domain_scores_codex":[0.9984982,0.0002100418,0.0006732648,0.000376958,0.00006775544,0.0001737681],"domain_scores_gemma":[0.997255,0.0003130618,0.0002472329,0.001834496,0.00029675,0.00005348845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5893803,0.0287695,0.0008663885,0.0002865133,0.001890312,0.000001079581,0.002072619,0.0001810642,0.3094998,0.002436784,0.0006221108,0.06399361],"study_design_scores_gemma":[0.9013096,0.006362562,0.001166458,0.0003030826,0.0007181425,0.00001543021,0.00407492,0.0313582,0.04146907,0.0007708667,0.0114676,0.000984036],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802827,0.008209306,0.002781972,0.0009420872,0.00004466479,0.007079508,0.0001443867,0.00002551443,0.0004899147],"genre_scores_gemma":[0.9697175,0.002326664,0.02527129,0.0004481492,0.00001710047,0.00159491,0.0004926226,0.00001565744,0.0001161088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3119294,"threshold_uncertainty_score":0.6013798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02939266523028675,"score_gpt":0.3794311431801531,"score_spread":0.3500384779498663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}