{"id":"W4406136889","doi":"10.1038/s41467-025-55843-9","title":"Safety and immunogenicity of an optimized self-replicating RNA platform for low dose or single dose vaccine applications: a randomized, open label Phase I study in healthy volunteers","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Cancer Institute; King Saud University","keywords":"Immunogenicity; Immunity; Immune system; Adverse effect; Medicine; Immunology; Virology; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001250691,0.0005925103,0.0007683329,0.0002037885,0.0001794886,0.0004251585,0.000339051,0.0008737368,0.001465262],"category_scores_gemma":[0.0005680689,0.0002707354,0.0004138827,0.0001698619,0.0005721513,0.0004498806,0.0001771381,0.001087586,0.0003249073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000250928,"about_ca_system_score_gemma":0.000473201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001722188,"about_ca_topic_score_gemma":0.0002950362,"domain_scores_codex":[0.9994476,0.000254364,0.00003390164,0.0001201874,0.00008514579,0.00005870357],"domain_scores_gemma":[0.9996419,0.00007505043,0.0001513755,0.00003714723,0.00003827688,0.00005625371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1432798,0.05136767,0.002345237,0.0008505445,0.000456454,0.0001188095,0.0002226823,0.002275293,0.7068166,0.0003774171,0.001324396,0.09056506],"study_design_scores_gemma":[0.02842666,0.8855448,0.004231823,0.00001750819,0.0002816672,0.0001444069,0.00003597563,0.001878015,0.07715008,0.0001409211,0.002115326,0.00003274132],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928886,0.0007009042,0.003904096,0.00008345782,0.00007839486,0.001502344,0.0003078843,0.00008789117,0.0004464175],"genre_scores_gemma":[0.9872541,0.0005261897,0.008082352,0.000230045,0.00007458724,0.001696444,0.0004527746,0.00003924112,0.001644269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001465262,"threshold_uncertainty_score":0.006614327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02939266523028675,"score_gpt":0.3794311431801531,"score_spread":0.3500384779498663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}