{"id":"W4406138855","doi":"10.26508/lsa.202403021","title":"lncRNA <i>CARINH</i> regulates expression and function of innate immune transcription factor IRF1 in macrophages","year":2025,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; American Heart Association","keywords":"IRF1; Biology; Innate immune system; Gene; Interferon; Regulation of gene expression; Immune system; Virus; Transcription factor; Gene expression; Virology; Long non-coding RNA; RNA; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001026619,0.0001526395,0.0001237856,0.0001711759,0.0002498413,0.000320131,0.0001338432,0.0001784254,0.001978908],"category_scores_gemma":[0.0000866233,0.00007556971,0.000201602,0.00009928415,0.0002051884,0.0001723599,0.0002231111,0.0003566485,0.0004008664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003101513,"about_ca_system_score_gemma":0.0003164372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009677307,"about_ca_topic_score_gemma":0.002061094,"domain_scores_codex":[0.9998949,0.000009573961,0.000004427222,0.00003524884,0.00002340049,0.00003255328],"domain_scores_gemma":[0.9999267,0.00001143122,0.00002177563,0.000008148606,0.00001324368,0.00001863042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005948717,0.000006492403,0.00146048,0.00002535008,0.000003611431,0.00005541457,0.00001552774,0.00004639808,0.9962685,0.0001881609,0.0001161724,0.001754445],"study_design_scores_gemma":[0.00001446289,0.0001406295,0.04833978,0.00001100569,0.00002631186,0.0006183264,0.0001425915,0.001530498,0.93615,0.0002638572,0.012749,0.00001350773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864165,0.002510587,0.004579453,0.000346912,0.00006390612,0.00002263393,0.0009054951,0.0002646262,0.004889984],"genre_scores_gemma":[0.9930078,0.0005524614,0.002004296,0.0002266566,0.00001829442,0.00001930327,0.0007155732,0.00002941723,0.003426144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001978908,"threshold_uncertainty_score":0.006620109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008802254918084137,"score_gpt":0.268793634442902,"score_spread":0.2599913795248179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}