{"id":"W4406140461","doi":"10.1002/1878-0261.13793","title":"Polyfunctional <scp>CD</scp> 8 <sup>+</sup> <scp>CD</scp> 226 <sup>+</sup> <scp>RUNX</scp> 2 <sup>hi</sup> effector T cells are diminished in advanced stages of chronic lymphocytic leukemia","year":2025,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"University of Alberta; Cancer Research Society","keywords":"Cytokine; Biology; CD8; Chemokine; Cytotoxic T cell; Degranulation; CCL5; Immunology; Effector; IL-2 receptor; Cell biology; Immune system; T cell; Molecular biology; Receptor; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.001358892,0.001726266,0.002824944,0.002035419,0.0007164159,0.0001373565,0.001535674,0.002802896,0.0008642309],"category_scores_gemma":[0.00347964,0.001831416,0.001216277,0.001845981,0.001161833,0.0006388663,0.0008723708,0.002658005,0.002477428],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008827091,"about_ca_system_score_gemma":0.004698655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006847451,"about_ca_topic_score_gemma":0.0001305261,"domain_scores_codex":[0.9888511,0.002807675,0.002647209,0.002459029,0.000503612,0.00273132],"domain_scores_gemma":[0.9902582,0.005472115,0.001377765,0.001876087,0.0007278475,0.0002879856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004702423,0.001499533,0.003268524,0.0008152637,0.002421506,0.0005958877,0.002870237,0.1466273,0.6943767,0.0007441704,0.1406952,0.005615392],"study_design_scores_gemma":[0.01576901,0.003858746,0.005359871,0.0005796326,0.0007807052,0.0003265959,0.006863164,0.008521917,0.3517963,0.0001690494,0.6055949,0.0003800968],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674286,0.01114384,0.00197972,0.0002273716,0.004653728,0.002247685,0.0002034773,0.0005349827,0.01158056],"genre_scores_gemma":[0.9367105,0.001026614,0.0003328465,0.002614079,0.0003241592,0.0008420603,0.001515112,0.0002735197,0.05636109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4648997,"threshold_uncertainty_score":0.9996429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0061226885787524,"score_gpt":0.237948142836371,"score_spread":0.2318254542576186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}