{"id":"W4406144247","doi":"10.1158/1541-7786.mcr-24-0958","title":"Exploring B7-H4’s Role in Prostate Cancer Dormancy after Androgen Deprivation Therapy: Extracellular Matrix Interactions and Therapeutic Opportunities","year":2025,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia; Richmond Hospital; University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Mitacs; Terry Fox Research Institute; National Cancer Institute; BC Cancer Foundation; Pacific Northwest Foundation","keywords":"Prostate cancer; Dormancy; LNCaP; Cancer research; Androgen deprivation therapy; Extracellular matrix; Biology; In vivo; Cancer; Medicine; Internal medicine; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005314911,0.0002027405,0.0002706415,0.000933834,0.0001724828,0.0001072815,0.0001244729,0.00006059958,0.0002363721],"category_scores_gemma":[0.00001799926,0.0001696721,0.00006982727,0.0008731282,0.0001992425,0.0002437531,0.0001310561,0.0006041549,0.000006519771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005308596,"about_ca_system_score_gemma":0.0006366397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002270847,"about_ca_topic_score_gemma":0.0004359538,"domain_scores_codex":[0.9978369,0.0002135358,0.0002843462,0.0004631895,0.0005706965,0.0006312573],"domain_scores_gemma":[0.9991052,0.0000638159,0.00003514826,0.0003452823,0.0003021758,0.0001484436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005102521,0.0004476954,0.2565438,0.000659159,0.0006823066,0.00115472,0.00432858,0.00008007198,0.2942568,0.0009679507,0.0001581465,0.4356182],"study_design_scores_gemma":[0.01394579,0.0008371224,0.1820959,0.003598157,0.0001904985,0.00004613483,0.007493797,0.002138173,0.6197494,0.003211999,0.1657813,0.0009117253],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8318559,0.1603874,0.00002561056,0.005872549,0.00009393022,0.001200776,0.00001908581,0.00003466877,0.0005100892],"genre_scores_gemma":[0.9164932,0.07186852,0.00003870533,0.0001431218,0.0000494642,0.004902695,0.00002203529,0.00003981136,0.006442491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4347065,"threshold_uncertainty_score":0.6919026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1851894975281793,"score_gpt":0.4223734758698284,"score_spread":0.2371839783416491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}