{"id":"W4406146939","doi":"10.51731/cjht.25.1053","title":"Exagamglogene autotemcel (Casgevy)","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Health Technologies","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Thalassemia; Medicine; Hematologist; Beta thalassemia; Red Cell; Malignancy; Pediatrics; Hematopoietic stem cell; Hemoglobinopathy; Hematopoietic stem cell transplantation; Internal medicine; Stem cell; Transplantation; Haematopoiesis; Hemolytic anemia; Biology; Genetics; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003695095,0.0003925234,0.0004325777,0.0009144594,0.0004702431,0.001007486,0.000487057,0.0005402644,0.1022459],"category_scores_gemma":[0.0008905496,0.0001594325,0.0003285871,0.0005053414,0.0003503452,0.0003489937,0.0006938124,0.000877526,0.03370393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007903234,"about_ca_system_score_gemma":0.001987302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008710327,"about_ca_topic_score_gemma":0.01415082,"domain_scores_codex":[0.999692,0.00003898694,0.00001391674,0.00005401106,0.0001562714,0.00004484726],"domain_scores_gemma":[0.9995942,0.00007157018,0.00004353223,0.00004513931,0.000104155,0.0001414952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001693831,0.0003200192,0.003301128,0.0006831039,0.00004224845,0.001214484,0.0001256132,0.0001953636,0.03127307,0.005574478,0.2770698,0.6785069],"study_design_scores_gemma":[0.000243893,0.0002539511,0.002900661,0.0001316411,0.00003146375,0.002499971,0.00002626717,0.0002298753,0.01047422,0.0003742576,0.9828231,0.00001069153],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.08305614,0.07365835,0.02192942,0.00747728,0.002550319,0.001279663,0.02177409,0.01719947,0.7710752],"genre_scores_gemma":[0.3122548,0.0307472,0.02780141,0.007089359,0.0007241455,0.0006011383,0.02785837,0.002618331,0.5903052],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.1022459,"threshold_uncertainty_score":0.3420467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01405925881571105,"score_gpt":0.2787795237020159,"score_spread":0.2647202648863048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}