{"id":"W4406146972","doi":"10.51731/cjht.25.1052","title":"Exagamglogene Autotemcel (Casgevy)","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Health Technologies","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Hematologist; Internal medicine; Disease; Transcranial Doppler; Stem cell; Hematopoietic stem cell transplantation; Oncology; Pediatrics; Surgery","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000396712,0.0003419396,0.0003938785,0.00101737,0.0005360845,0.0009685041,0.0004031523,0.0005962697,0.08548701],"category_scores_gemma":[0.001029465,0.0001398221,0.0003364476,0.0004994353,0.0003909041,0.0003574249,0.0006435816,0.0009249345,0.02277006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007441608,"about_ca_system_score_gemma":0.001839254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008054521,"about_ca_topic_score_gemma":0.01373044,"domain_scores_codex":[0.9996891,0.00003906022,0.00001470106,0.00004989707,0.0001602545,0.00004700396],"domain_scores_gemma":[0.9994711,0.00009857403,0.00005887792,0.000055026,0.0001264788,0.0001899066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001625155,0.0003738709,0.004172158,0.0005879881,0.00004083677,0.001698236,0.0001196741,0.0001776094,0.02038408,0.004676933,0.2373005,0.7288431],"study_design_scores_gemma":[0.0002933731,0.0003758068,0.004636762,0.0001876467,0.00003256895,0.004134018,0.0000326958,0.0002381913,0.008848677,0.000420334,0.9807876,0.00001223478],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.1041034,0.1056926,0.01755688,0.009443146,0.003496524,0.001227909,0.01522953,0.01194467,0.7313052],"genre_scores_gemma":[0.4109375,0.03690309,0.0250812,0.008152395,0.00131329,0.0005161302,0.01779278,0.001812156,0.4974915],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.08548701,"threshold_uncertainty_score":0.2859825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01405925881571105,"score_gpt":0.2787795237020159,"score_spread":0.2647202648863048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}