{"id":"W4406147362","doi":"10.1002/jcph.6179","title":"Pharmacokinetics and Pharmacodynamics of Intravenous Magnesium Sulfate in Pediatric Acute Asthma Exacerbations","year":2025,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Magnesium in Health and Disease","field":"Nursing","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Maternal and Child Health Bureau; School of Medicine, Emory University; National Center for Advancing Translational Sciences; Health Resources and Services Administration; University at Buffalo; Scheme for Promotion of Academic and Research Collaboration; National Heart, Lung, and Blood Institute; Seattle Children's Research Institute; National Institutes of Health; U.S. Department of Health and Human Services; Cincinnati Children's Hospital Medical Center; Emory University; Nationwide Children's Hospital","keywords":"Medicine; Emergency department; Asthma; Exacerbation; Asthma exacerbations; Acute severe asthma; Pharmacokinetics; Anesthesia; Dosing; Pharmacodynamics; Placebo; Area under the curve; Refractory (planetary science); Intensive care medicine; Internal medicine; Respiratory disease; Lung","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007926604,0.0002147992,0.0005456189,0.000159355,0.00009062601,0.0004891192,0.0002206036,0.0003365055,0.0003864808],"category_scores_gemma":[0.00287041,0.0001385083,0.0002859767,0.000230832,0.0002097461,0.0002283459,0.0001720791,0.000584631,0.0001003966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003450255,"about_ca_system_score_gemma":0.0004209417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001029779,"about_ca_topic_score_gemma":0.0008166275,"domain_scores_codex":[0.9994283,0.0002856658,0.00002816265,0.00006113601,0.0001558838,0.00004087626],"domain_scores_gemma":[0.9987738,0.0004649845,0.0004955601,0.00006859934,0.00008805617,0.0001090365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03125563,0.001462871,0.7749371,0.0004708245,0.0008760338,0.0009384364,0.0005627276,0.009725737,0.06468925,0.0005434323,0.001842634,0.1126953],"study_design_scores_gemma":[0.001048667,0.03004242,0.9183288,0.00006278321,0.0003968912,0.001543903,0.000323567,0.02376595,0.0204535,0.0003650138,0.003636604,0.00003192242],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974208,0.001189416,0.0008544101,0.0000820786,0.000007193842,0.00003189714,0.0001250365,0.00001563763,0.000273556],"genre_scores_gemma":[0.9989576,0.0003330792,0.0004703353,0.0000416452,0.00001109425,0.00001834401,0.0000937169,0.00000454363,0.00006949429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001029779,"threshold_uncertainty_score":0.004192054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02480889781505559,"score_gpt":0.4197764211743215,"score_spread":0.3949675233592659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}