{"id":"W4406149104","doi":"10.1016/j.oooo.2024.10.103","title":"Results of a phase 1, open-label, dose-escalation study of gene therapy with AAV2-hAQP1 as treatment for grade 2 and 3 radiation-induced late xerostomia and parotid gland hypofunction","year":2025,"lang":"en","type":"article","venue":"Oral Surgery Oral Medicine Oral Pathology and Oral Radiology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences North; Science North","funders":"","keywords":"Medicine; Parotid gland; Radiation therapy; Phase (matter); Internal medicine; Oncology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001802266,0.00153445,0.00201317,0.0004296637,0.0005491253,0.001037736,0.0008235592,0.00140656,0.0021361],"category_scores_gemma":[0.0007304661,0.0004838027,0.001438002,0.0003712955,0.001134038,0.0009297198,0.0001908274,0.003409342,0.0004370094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001091114,"about_ca_system_score_gemma":0.001670273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00162302,"about_ca_topic_score_gemma":0.003782059,"domain_scores_codex":[0.9994404,0.0001958562,0.00002550013,0.0001042645,0.00007817682,0.0001558691],"domain_scores_gemma":[0.9993709,0.0001269247,0.0001401054,0.00007203814,0.00005724025,0.0002328971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.299968,0.2415307,0.004286023,0.0008604497,0.001562883,0.0002895133,0.0005871648,0.007356385,0.3303091,0.0005862303,0.005159514,0.1075041],"study_design_scores_gemma":[0.127628,0.825298,0.01265248,0.00004015581,0.0007096092,0.0003329129,0.0001402624,0.002272209,0.02682693,0.0004191217,0.003626294,0.00005406982],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919614,0.001258228,0.001700093,0.0003146046,0.0001400123,0.002359956,0.001124315,0.0001054812,0.00103588],"genre_scores_gemma":[0.9860632,0.001531564,0.003433474,0.0006082311,0.0001092025,0.002873453,0.002364593,0.000075177,0.00294119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0021361,"threshold_uncertainty_score":0.009531379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04605330550904897,"score_gpt":0.3400204267100869,"score_spread":0.293967121201038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}