{"id":"W4406151778","doi":"10.3390/cells14020064","title":"Transcriptomic and Functional Landscape of Adult Human Spinal Cord NSPCs Compared to iPSC-Derived Neural Progenitor Cells","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Ottawa Hospital Research Institute; University of Ottawa","keywords":"Neurogenesis; Biology; Transcriptome; Progenitor cell; Neural stem cell; Induced pluripotent stem cell; Spinal cord; Axon; Cell biology; Neuroscience; Stem cell; Gene expression; Genetics; Gene; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001055297,0.0002002132,0.0002108145,0.0004689846,0.0001540996,0.000336243,0.00007145028,0.0001819293,0.0009765322],"category_scores_gemma":[0.0002015344,0.00008564073,0.0001927774,0.0003628181,0.000175564,0.0001303772,0.0001887348,0.000251309,0.0003366624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001056092,"about_ca_system_score_gemma":0.0001944385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005828261,"about_ca_topic_score_gemma":0.0006820461,"domain_scores_codex":[0.9998715,0.000008647122,0.00001305075,0.00004642819,0.00003998328,0.00002050655],"domain_scores_gemma":[0.9998829,0.00002405018,0.00002972183,0.000008911287,0.00003276303,0.00002166431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009742693,0.000007588763,0.002050525,0.00004984906,0.00001056348,0.00004945556,0.00005098129,0.00007431675,0.9954484,0.00003112039,0.00003477514,0.002094973],"study_design_scores_gemma":[0.00001639214,0.0005599568,0.4398475,0.00006925194,0.0001897202,0.001111275,0.0006563934,0.002972366,0.5454665,0.0002626744,0.008813865,0.00003411372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888992,0.001413187,0.002440744,0.00004698114,0.00001187792,0.00003471487,0.005744156,0.00004128816,0.001367798],"genre_scores_gemma":[0.9764889,0.001979867,0.003897863,0.0001454082,0.00002293108,0.0001949121,0.01443517,0.00005419988,0.002780833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009765322,"threshold_uncertainty_score":0.003266811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01753004996838935,"score_gpt":0.2788232248534444,"score_spread":0.261293174885055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}