{"id":"W4406151778","doi":"10.3390/cells14020064","title":"Transcriptomic and Functional Landscape of Adult Human Spinal Cord NSPCs Compared to iPSC-Derived Neural Progenitor Cells","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Ottawa Hospital Research Institute; University of Ottawa","keywords":"Neurogenesis; Biology; Transcriptome; Progenitor cell; Neural stem cell; Induced pluripotent stem cell; Spinal cord; Axon; Cell biology; Neuroscience; Stem cell; Gene expression; Genetics; Gene; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007892861,0.0001608059,0.000203681,0.0000958969,0.00008816617,0.00002538552,0.0001841236,0.0001086648,0.00005076027],"category_scores_gemma":[0.000008827437,0.0001593153,0.00008571981,0.0001254599,0.0001010281,0.000003538658,0.00010865,0.0001020374,0.0000150294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001152853,"about_ca_system_score_gemma":0.00006659418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001910273,"about_ca_topic_score_gemma":0.00002249854,"domain_scores_codex":[0.9988692,0.00005907833,0.0002455231,0.000382265,0.0001713847,0.0002725701],"domain_scores_gemma":[0.9993991,0.000009333572,0.00004722998,0.0002577212,0.0001635996,0.0001229843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008951883,0.00008765375,0.001056415,0.0001274559,0.0000543821,0.000004417938,0.00001759836,0.0000597571,0.9911988,0.00001598152,0.006047823,0.0004345264],"study_design_scores_gemma":[0.001012813,0.000555112,0.006038192,0.00003097561,0.00002428474,0.000005058236,0.0000709368,0.0002139654,0.9883038,0.000008959643,0.003586607,0.0001492576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972934,0.0003361834,0.0003669783,0.0001336063,0.0002932048,0.0004104786,0.00004839271,0.00001100434,0.001106741],"genre_scores_gemma":[0.9970248,0.00003370875,0.0002150481,0.0001507228,0.0001006528,0.00002680062,0.00008068224,0.00001515872,0.00235244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004981778,"threshold_uncertainty_score":0.6496689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01753004996838935,"score_gpt":0.2788232248534444,"score_spread":0.261293174885055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}