{"id":"W4406153852","doi":"10.3390/vaccines13010047","title":"A Spike-Based mRNA Vaccine Encapsulated in Phospholipid 1,2-Dioleoyl-sn-Glycero-3-PhosphoEthanolamine Containing Lipid Nanoparticles Induced Potent B- and T-Cell Responses Associated with Protection Against SARS-CoV-2 Infection and COVID-19-like Symptoms in Hamsters","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada)","funders":"National Institute of Allergy and Infectious Diseases; University of California, Irvine","keywords":"Immunogenicity; Proinflammatory cytokine; Messenger RNA; Chemistry; Hamster; Phospholipid; Exosome; Virology; Antigen; Biology; Immunology; Molecular biology; Microvesicles; Biochemistry; Inflammation; microRNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001019169,0.0003874573,0.0002110158,0.0001503855,0.00006982095,0.0001219103,0.0001190882,0.0002803529,0.0005487909],"category_scores_gemma":[0.0001149151,0.00009352714,0.0002309947,0.00007820546,0.0001829098,0.0001814759,0.0001328247,0.0003345343,0.0001566523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001880015,"about_ca_system_score_gemma":0.0001860126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002928827,"about_ca_topic_score_gemma":0.000447231,"domain_scores_codex":[0.9999273,0.000009437096,0.000006623959,0.00001697733,0.00002081277,0.00001872668],"domain_scores_gemma":[0.9999411,0.0000111455,0.00001721269,0.000004776551,0.00001402928,0.00001175134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005134207,0.00001836751,0.00005088756,0.00002473587,0.00000263463,0.00001386309,0.000004987758,0.00005911612,0.9990495,0.00001583456,0.00001014814,0.0006986095],"study_design_scores_gemma":[0.00001056744,0.0007079199,0.0006421443,0.000002537079,0.00001476901,0.00003426344,0.000007204329,0.0005030512,0.9975916,0.00001468917,0.0004691241,0.00000210065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964764,0.0004031605,0.002284539,0.00004219969,0.00002872803,0.00003159104,0.0001049867,0.00005098022,0.000577409],"genre_scores_gemma":[0.9951001,0.0003893277,0.002773692,0.00004592013,0.00001310848,0.00003503154,0.0002444788,0.00001503765,0.001383285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005487909,"threshold_uncertainty_score":0.001835823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01772264791507463,"score_gpt":0.2615455959993843,"score_spread":0.2438229480843096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}