{"id":"W4406153852","doi":"10.3390/vaccines13010047","title":"A Spike-Based mRNA Vaccine Encapsulated in Phospholipid 1,2-Dioleoyl-sn-Glycero-3-PhosphoEthanolamine Containing Lipid Nanoparticles Induced Potent B- and T-Cell Responses Associated with Protection Against SARS-CoV-2 Infection and COVID-19-like Symptoms in Hamsters","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada)","funders":"National Institute of Allergy and Infectious Diseases; University of California, Irvine","keywords":"Immunogenicity; Proinflammatory cytokine; Messenger RNA; Chemistry; Hamster; Phospholipid; Exosome; Virology; Antigen; Biology; Immunology; Molecular biology; Microvesicles; Biochemistry; Inflammation; microRNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003907002,0.000314799,0.0003471524,0.0003689469,0.0001070613,0.00006495866,0.00009611506,0.0002808486,0.000001646382],"category_scores_gemma":[0.0005377019,0.0002853014,0.00004469918,0.0005544907,0.00003302147,0.00002151021,0.00008776216,0.0002041013,7.828789e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001251689,"about_ca_system_score_gemma":0.0002410076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001440146,"about_ca_topic_score_gemma":0.004646113,"domain_scores_codex":[0.9983121,0.0002037003,0.0004278415,0.0006011177,0.0001055778,0.0003496273],"domain_scores_gemma":[0.9993012,0.00005234006,0.0001792324,0.0002415107,0.0001478441,0.00007786573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003636945,0.000153791,0.156417,0.00006454808,0.00005360675,0.00001386245,0.0001105963,0.0003219301,0.837347,0.000001608385,0.00005700913,0.001822086],"study_design_scores_gemma":[0.006323742,0.001335936,0.1362501,0.0003051027,0.00003298569,0.000006401029,0.0001055568,0.001815576,0.853258,0.00001014492,0.0002559901,0.0003005505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980516,0.0006153184,0.0001178688,0.0002818155,0.0001549255,0.0006769775,0.000009886415,0.00004481589,0.00004683493],"genre_scores_gemma":[0.9983,0.0003034998,0.00002086023,0.001056796,0.00003726509,0.0001315242,0.00006059154,0.00002460167,0.00006489508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02016688,"threshold_uncertainty_score":0.9999599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01772264791507463,"score_gpt":0.2615455959993843,"score_spread":0.2438229480843096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}