{"id":"W4406155097","doi":"10.1371/journal.pntd.0012763","title":"Pharmacological inhibition of key metabolic pathways attenuates Leishmania spp infection in macrophages","year":2025,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Fundação de Amparo à Pesquisa do Estado da Bahia; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação Oswaldo Cruz; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Leishmania; Biology; Glycolysis; Cell biology; Immune system; Mitochondrion; Leishmania braziliensis; Metabolic pathway; Macrophage; Innate immune system; Oxidative phosphorylation; Anaerobic glycolysis; Metabolism; Metabolome; Metabolomics; Microbiology; Parasite hosting; Biochemistry; Cutaneous leishmaniasis; Immunology; Leishmaniasis; In vitro; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001775253,0.0003006083,0.0003183126,0.0001985099,0.0001641987,0.0002551343,0.000239416,0.0002418435,0.001643298],"category_scores_gemma":[0.0001415002,0.000123554,0.0002432387,0.0001303402,0.0002350397,0.0001958313,0.0002203219,0.0007646997,0.000265133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001371384,"about_ca_system_score_gemma":0.0003640125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006946487,"about_ca_topic_score_gemma":0.001730058,"domain_scores_codex":[0.999869,0.00002763509,0.00001400532,0.00001666709,0.00002330117,0.00004939712],"domain_scores_gemma":[0.9999199,0.00001260078,0.0000184563,0.00000777285,0.00001337277,0.00002786683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001438017,0.0003777929,0.0001906404,0.0002056198,0.00001800631,0.00006202045,0.00004813681,0.00009153388,0.9924367,0.0001486824,0.0001769009,0.004805927],"study_design_scores_gemma":[0.0002995867,0.007313155,0.008253004,0.00006416053,0.00008573361,0.0002463503,0.0001663837,0.001274588,0.9748592,0.000187258,0.007236493,0.00001407879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986703,0.006189439,0.001819679,0.0004712309,0.0001349381,0.0001062554,0.0005890919,0.0001830154,0.003803291],"genre_scores_gemma":[0.9927938,0.003103587,0.001320504,0.0001787276,0.00002801588,0.000081739,0.0004178524,0.00001612741,0.002059632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001643298,"threshold_uncertainty_score":0.005497396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02695096271571795,"score_gpt":0.3014617085629778,"score_spread":0.2745107458472598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}