{"id":"W4406155728","doi":"10.1152/ajplung.00188.2024","title":"Role of voltage-gated Ca 2+ channels and Ano1 Ca 2+ -activated Cl − channels in M2 muscarinic receptor-dependent contractions of murine airway smooth muscle","year":2025,"lang":"en","type":"article","venue":"American Journal of Physiology-Lung Cellular and Molecular Physiology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Higher Education Authority; European Commission","keywords":"Thapsigargin; SERCA; Carbachol; Cholinergic; Internal medicine; Muscarinic acetylcholine receptor; Endocrinology; Chemistry; Nifedipine; Channel blocker; Muscarinic antagonist; Apamin; Endoplasmic reticulum; Stimulation; Biology; Potassium channel; Calcium; Receptor; Biochemistry; ATPase; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002261317,0.0002783009,0.0002126082,0.0001408433,0.0001613006,0.0002968365,0.0002265313,0.0003765966,0.0005679287],"category_scores_gemma":[0.0001847557,0.00009462138,0.0002185265,0.0000609507,0.0002764775,0.0003695686,0.0002111474,0.0003345716,0.0001195274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001570824,"about_ca_system_score_gemma":0.0002098599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002283501,"about_ca_topic_score_gemma":0.0003725764,"domain_scores_codex":[0.9998864,0.00001863731,0.00001258664,0.00002163678,0.00002231218,0.00003841509],"domain_scores_gemma":[0.9998186,0.00003134625,0.00006130651,0.00001775609,0.00001832041,0.00005266327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002101651,0.00001097213,0.0003248635,0.00003962549,0.000003605055,0.00008043244,0.00001714587,0.00003142779,0.998442,0.0001610257,0.00001291658,0.0006658469],"study_design_scores_gemma":[0.00007883339,0.001021234,0.02541417,0.00002622593,0.00004888481,0.0008644636,0.0001090438,0.001514424,0.9675263,0.0003404507,0.003043884,0.00001211003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925731,0.002953022,0.002736938,0.0001688175,0.00002296454,0.00001892233,0.0001038164,0.00002947131,0.00139289],"genre_scores_gemma":[0.9954967,0.001192535,0.002069874,0.00007643044,0.00001425931,0.000031911,0.0001185727,0.000006010584,0.0009936991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005679287,"threshold_uncertainty_score":0.001899958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006752512807266331,"score_gpt":0.2365495825135698,"score_spread":0.2297970697063035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}