{"id":"W4406168419","doi":"10.1093/brain/awae339","title":"Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; NIH Office of the Director; National Institute of Mental Health; University College London Hospitals Biomedical Research Centre; Medical Research Council; National Cancer Institute; National Institutes of Health; National Institute for Health and Care Research; UK Dementia Research Institute; Medical Research Council Canada; University College London","keywords":"Biology; Microglia; Gene; Longevity; Ageing; Transcriptome; Genome-wide association study; Neurodegeneration; Alzheimer's disease; Genetics; Oligodendrocyte; Neuroscience; Gene expression; Disease; Single-nucleotide polymorphism; Central nervous system; Immunology; Medicine; Myelin; Inflammation; Genotype; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001425191,0.0001604544,0.0001378404,0.00009789853,0.0003499966,0.0001409418,0.0001279441,0.00004933283,0.00003927436],"category_scores_gemma":[0.0001312871,0.000163836,0.00003077748,0.0001704711,0.00008978403,0.0001675243,0.0001349125,0.0001274709,0.00001157472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007481728,"about_ca_system_score_gemma":0.00002667805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000320802,"about_ca_topic_score_gemma":0.000009243578,"domain_scores_codex":[0.9987516,0.0002077216,0.0001998893,0.0005068851,0.0001220246,0.0002118821],"domain_scores_gemma":[0.9993747,0.0001069112,0.00006599131,0.0002639288,0.00001478008,0.000173614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003006436,0.00002906721,0.0002127558,0.00001003316,0.000004427533,0.00006146875,0.00002381898,0.00006453812,0.9863237,0.008742427,0.001345052,0.003152699],"study_design_scores_gemma":[0.0007940054,0.00003811445,0.02314926,0.00001733887,0.00004412161,0.00003601425,0.000001904663,0.01817282,0.9534397,0.001371946,0.0026955,0.0002392936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884628,0.000311468,0.00731232,0.002486862,0.0003525349,0.0004165649,0.00001756804,0.0001473041,0.0004925932],"genre_scores_gemma":[0.9906223,0.00008364732,0.0001508209,0.007648712,0.00006844992,0.00001508277,0.000004616727,0.00001647077,0.001389836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03288396,"threshold_uncertainty_score":0.6681039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02637443810910027,"score_gpt":0.279541576836667,"score_spread":0.2531671387275667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}