{"id":"W4406168419","doi":"10.1093/brain/awae339","title":"Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; NIH Office of the Director; National Institute of Mental Health; University College London Hospitals Biomedical Research Centre; Medical Research Council; National Cancer Institute; National Institutes of Health; National Institute for Health and Care Research; UK Dementia Research Institute; Medical Research Council Canada; University College London","keywords":"Biology; Microglia; Gene; Longevity; Ageing; Transcriptome; Genome-wide association study; Neurodegeneration; Alzheimer's disease; Genetics; Oligodendrocyte; Neuroscience; Gene expression; Disease; Single-nucleotide polymorphism; Central nervous system; Immunology; Medicine; Myelin; Inflammation; Genotype; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001273313,0.0001997514,0.0001948497,0.0004331698,0.000165039,0.0002637956,0.00009868685,0.0001393419,0.001196692],"category_scores_gemma":[0.0003269509,0.00009131209,0.0002885404,0.0004897168,0.0001599109,0.0001597728,0.0002807782,0.0001698434,0.0001233986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001563847,"about_ca_system_score_gemma":0.0001489366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00215819,"about_ca_topic_score_gemma":0.003220618,"domain_scores_codex":[0.9998623,0.00002386928,0.000006997301,0.00006325271,0.00002307112,0.00002040461],"domain_scores_gemma":[0.9998544,0.00003212642,0.00006548574,0.00001276639,0.00001405582,0.00002114451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00139577,0.00006340192,0.4203798,0.0002904199,0.0008631132,0.0008564091,0.0005010354,0.001952008,0.5347285,0.001963985,0.001050221,0.03595535],"study_design_scores_gemma":[0.00001595192,0.0001274813,0.9851703,0.00002780979,0.0002501445,0.0007160078,0.0001071685,0.001792634,0.007939631,0.001520731,0.002317936,0.00001407022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944019,0.001507153,0.001852841,0.00008420195,0.000009776642,0.000006574985,0.001254534,0.00003207267,0.0008510927],"genre_scores_gemma":[0.9961219,0.0005927855,0.00161192,0.00006357832,0.000009835569,0.00001361515,0.000954736,0.00001289934,0.0006186152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00215819,"threshold_uncertainty_score":0.004291177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02637443810910027,"score_gpt":0.279541576836667,"score_spread":0.2531671387275667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}