{"id":"W4406168575","doi":"10.1101/2025.01.08.631940","title":"Cell-type specific transcriptional modulation by psilocybin induces sustained plasticity in mouse medial prefrontal cortex","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mila - Quebec Artificial Intelligence Institute; McGill Genome Centre; Montreal Neurological Institute and Hospital; McGill University","funders":"","keywords":"Psilocybin; Prefrontal cortex; Neuroscience; Neuroplasticity; Cell type; Plasticity; Cell; Biology; Hallucinogen; Cognition; Genetics; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000865537,0.0002401528,0.0001917199,0.0002862721,0.0001119624,0.000194836,0.0001377005,0.0002053606,0.001822143],"category_scores_gemma":[0.00005913925,0.0001434707,0.0002267582,0.0001315004,0.0002714749,0.0001297576,0.0001458719,0.0005295908,0.0003457459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002952979,"about_ca_system_score_gemma":0.0001312222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009378979,"about_ca_topic_score_gemma":0.002404721,"domain_scores_codex":[0.9998959,0.000007326211,0.000005356251,0.00003546126,0.00002275338,0.00003319334],"domain_scores_gemma":[0.9999193,0.000007727494,0.00003176726,0.000009316391,0.000007884588,0.00002395555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007221764,0.000005923921,0.00007239741,0.00001185115,0.000001626153,0.00001379195,0.000005115269,0.000007688777,0.9994647,0.00001260091,0.00001580523,0.0003163184],"study_design_scores_gemma":[0.00001965919,0.0004021723,0.02769852,0.00001130925,0.00001552594,0.0001384365,0.00005888991,0.0003752133,0.9700792,0.00004412195,0.001152052,0.000004890745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946761,0.0007986578,0.002101544,0.0001035333,0.00002356406,0.00001651812,0.001378431,0.00009271567,0.0008089477],"genre_scores_gemma":[0.9902492,0.0006486051,0.002636508,0.0001166074,0.000009097281,0.00005561865,0.001125558,0.00004352496,0.005115379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001822143,"threshold_uncertainty_score":0.006095707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02115316472580806,"score_gpt":0.2560668510871945,"score_spread":0.2349136863613864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}