{"id":"W4406169283","doi":"10.14309/ajg.0000000000003310","title":"Impact of Prior Biologic Exposure on Ozanimod Efficacy and Safety in the Phase 3 True North Clinical Trial","year":2025,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Penn West Exploration (Canada)","funders":"Pfizer; Allergan; Eli Lilly and Company; Bristol-Myers Squibb; Amgen","keywords":"Medicine; Internal medicine; Placebo; Clinical trial; Population; Surgery; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005534383,0.0003085945,0.0008867706,0.0001017494,0.0001931104,0.0005964359,0.0003857976,0.0003698864,0.004090771],"category_scores_gemma":[0.003475072,0.000190411,0.001147499,0.0001619351,0.0004531274,0.0006393894,0.0003706178,0.000760496,0.0002588108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004174363,"about_ca_system_score_gemma":0.000933143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003228958,"about_ca_topic_score_gemma":0.001491934,"domain_scores_codex":[0.9980025,0.001455078,0.00008809119,0.0001600727,0.0001911048,0.0001032589],"domain_scores_gemma":[0.9968376,0.001408238,0.001215438,0.0001834524,0.0001338451,0.0002214189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9208706,0.001807778,0.01864136,0.001408891,0.002181443,0.00009673656,0.0001650132,0.0009942062,0.003893867,0.0002485473,0.001291754,0.04839971],"study_design_scores_gemma":[0.4413269,0.3190623,0.2121958,0.0005976191,0.00653922,0.0007114829,0.0002235722,0.002887127,0.005557995,0.0009949945,0.009820785,0.00008216318],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991087,0.004600137,0.0004866368,0.0002681117,0.00005523388,0.0004726292,0.0004526846,0.00002629442,0.002551232],"genre_scores_gemma":[0.9964671,0.0009319645,0.0004992014,0.0001828011,0.00005579809,0.0004950172,0.0005289645,0.000008599569,0.0008305309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005534383,"threshold_uncertainty_score":0.02926898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0157940633594919,"score_gpt":0.3478727414298246,"score_spread":0.3320786780703327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}