{"id":"W4406169707","doi":"10.1093/neuonc/noae242","title":"Development and validation of a molecular classifier of meningiomas","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Meningioma and schwannoma management","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University of British Columbia; University Health Network","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Moonshot Research and Development Program; National Cancer Institute; Canadian Institutes of Health Research; Cancer Moonshot; School of Medicine, University of North Carolina at Chapel Hill; Broad Institute; University of Oklahoma Health Sciences Center; NRG Oncology; University Health Network Foundation; Leidos; Vanderbilt University Medical Center; Princess Margaret Hospital Foundation; Deutsches Krebsforschungszentrum; National Institutes of Health; School of Medicine, Case Western Reserve University; Brain Tumour Charity; University of Oklahoma; Case Comprehensive Cancer Center, Case Western Reserve University; Center for Biomedical Informatics and Information Technology, National Cancer Institute; Deutschen Konsortium für Translationale Krebsforschung; University of Pennsylvania; Vanderbilt University; Congress of Neurological Surgeons; Pennsylvania State University; V Foundation for Cancer Research; University of Toronto; Case Western Reserve University; Faculty of Medicine, University of British Columbia; U.S. Department of Health and Human Services","keywords":"DNA methylation; Biology; Methylation; Exome; Exome sequencing; Cell cycle; Computational biology; Bioinformatics; Oncology; Cancer research; DNA; Cell; Genetics; Medicine; Gene; Mutation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004258344,0.0008218165,0.0008762564,0.00239347,0.0005768454,0.001448253,0.001006772,0.001110218,0.0007504938],"category_scores_gemma":[0.007650655,0.0001683192,0.0008487728,0.0006473125,0.0003000757,0.0005884195,0.0008701493,0.001056204,0.0007212575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00109957,"about_ca_system_score_gemma":0.001748467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00218809,"about_ca_topic_score_gemma":0.001409339,"domain_scores_codex":[0.9984726,0.0002772094,0.0001961959,0.0004530809,0.0004305643,0.000170351],"domain_scores_gemma":[0.9948334,0.002139696,0.0006400272,0.0003614122,0.001722654,0.0003028532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001214767,0.001255241,0.6007711,0.0003008443,0.0007118555,0.000559436,0.0001426089,0.05352539,0.04099962,0.0008606349,0.007044917,0.2926135],"study_design_scores_gemma":[0.0001561744,0.001060471,0.08483025,0.00009998763,0.0004409411,0.0008987952,0.000158162,0.8592071,0.04682748,0.001755989,0.004515068,0.00004953567],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9066828,0.0006464292,0.08493195,0.0005315313,0.0001654373,0.0005235952,0.003488111,0.001321325,0.001708722],"genre_scores_gemma":[0.9248221,0.0001490396,0.06767395,0.0001425703,0.00008229114,0.0003165471,0.006236868,0.00003847173,0.0005382624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004258344,"threshold_uncertainty_score":0.0225206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03588568600568398,"score_gpt":0.307921973123315,"score_spread":0.2720362871176311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}