{"id":"W4406169707","doi":"10.1093/neuonc/noae242","title":"Development and validation of a molecular classifier of meningiomas","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Meningioma and schwannoma management","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University of British Columbia; University Health Network","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Moonshot Research and Development Program; National Cancer Institute; Canadian Institutes of Health Research; Cancer Moonshot; School of Medicine, University of North Carolina at Chapel Hill; Broad Institute; University of Oklahoma Health Sciences Center; NRG Oncology; University Health Network Foundation; Leidos; Vanderbilt University Medical Center; Princess Margaret Hospital Foundation; Deutsches Krebsforschungszentrum; National Institutes of Health; School of Medicine, Case Western Reserve University; Brain Tumour Charity; University of Oklahoma; Case Comprehensive Cancer Center, Case Western Reserve University; Center for Biomedical Informatics and Information Technology, National Cancer Institute; Deutschen Konsortium für Translationale Krebsforschung; University of Pennsylvania; Vanderbilt University; Congress of Neurological Surgeons; Pennsylvania State University; V Foundation for Cancer Research; University of Toronto; Case Western Reserve University; Faculty of Medicine, University of British Columbia; U.S. Department of Health and Human Services","keywords":"DNA methylation; Biology; Methylation; Exome; Exome sequencing; Cell cycle; Computational biology; Bioinformatics; Oncology; Cancer research; DNA; Cell; Genetics; Medicine; Gene; Mutation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002256002,0.00008382952,0.0002514359,0.0001974686,0.00001512833,0.00000552948,0.00004056204,0.00007085697,0.00005127877],"category_scores_gemma":[0.00005377235,0.00007308265,0.00004223143,0.000171249,0.00005732616,0.00003041451,0.00006379168,0.00008616595,0.000007585055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004514751,"about_ca_system_score_gemma":0.0001576827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002553547,"about_ca_topic_score_gemma":3.280957e-7,"domain_scores_codex":[0.9991497,0.0000508328,0.0003159311,0.0001995219,0.0001674658,0.000116537],"domain_scores_gemma":[0.9996136,0.00008744495,0.00006937327,0.0001264313,0.00004501898,0.00005815417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008143404,0.00006565786,0.0004078109,0.0003243127,0.0001017513,0.001338267,0.001108528,0.000003524561,0.9650893,0.004897094,0.0005910501,0.02599128],"study_design_scores_gemma":[0.0006444305,0.0007264221,0.001068957,0.00008436786,0.0001572099,0.0003798765,0.0001593575,0.0003709059,0.8367423,0.0001506858,0.1594427,0.00007270851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842647,0.0003752277,0.0008840317,0.0008123342,0.0001988481,0.0002247156,9.22679e-7,0.00003015442,0.01320912],"genre_scores_gemma":[0.9918621,0.000006571259,0.007867472,0.00007226124,0.00002148611,0.00001812481,0.000008287816,0.00001298051,0.0001306837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1588517,"threshold_uncertainty_score":0.2980224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03588568600568398,"score_gpt":0.307921973123315,"score_spread":0.2720362871176311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}