{"id":"W4406178968","doi":"10.7554/elife.102879","title":"Identification of neurodevelopmental organization of the cell populations of juvenile Huntington’s disease using dorso-ventral HD organoids and HD mouse embryos","year":2025,"lang":"en","type":"preprint","venue":"eLife","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Organoid; Huntington's disease; Biology; Juvenile; Embryo; Identification (biology); Disease; Neuroscience; Embryonic stem cell; Genetics; Pathology; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000149343,0.0002780031,0.0002334813,0.0005659625,0.0002098427,0.0003123534,0.0001574971,0.0002273735,0.00101527],"category_scores_gemma":[0.0000864519,0.0001789658,0.0003489341,0.0002239982,0.0002332154,0.0001317863,0.000276289,0.0004554531,0.000480378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002970199,"about_ca_system_score_gemma":0.0001502914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001079587,"about_ca_topic_score_gemma":0.002130494,"domain_scores_codex":[0.9998364,0.00001195321,0.00001944002,0.00006673156,0.00004265394,0.00002279074],"domain_scores_gemma":[0.9998521,0.00003395837,0.00003216081,0.00002445478,0.00002127494,0.00003606885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002471083,0.000003311879,0.0002067022,0.00001232618,0.000002443222,0.00003064246,0.00002675692,0.0000302,0.9993266,0.00002924214,0.00001295175,0.0002942137],"study_design_scores_gemma":[0.000006811703,0.0001055553,0.01485119,0.00001061632,0.00003024793,0.0003119009,0.0001092056,0.0007966206,0.9807457,0.00004004762,0.002983271,0.000008870844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657023,0.002278357,0.02212833,0.00007947794,0.00006736597,0.0001542796,0.006293263,0.000294942,0.003001691],"genre_scores_gemma":[0.9667825,0.001246078,0.01597427,0.00007365504,0.00001010226,0.0002622589,0.006734903,0.0001418864,0.008774231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001079587,"threshold_uncertainty_score":0.003396451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01481469936768669,"score_gpt":0.2657379314822393,"score_spread":0.2509232321145526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}