{"id":"W4406179279","doi":"10.21203/rs.3.rs-5524306/v1","title":"Structure-guided optimization of small molecules targeting the yeast casein kinase, Yck2, as a therapeutic strategy to combat Candida albicans","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of Toronto","funders":"Genentech; Canadian Institute for Advanced Research; Université de Nantes; National Institutes of Health; Ontario Genomics; Genome Canada; University of Texas Southwestern Medical Center; McGill University; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Bayer; Bristol-Myers Squibb","keywords":"Candida albicans; Yeast; Casein kinase 2; Casein kinase 1; Microbiology; Chemistry; Kinase; Medicine; Cancer research; Biology; Protein kinase A; Biochemistry; Mitogen-activated protein kinase kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001508839,0.0005276406,0.0004683424,0.0002198341,0.0001978598,0.0005621109,0.0003442552,0.0002630369,0.002269389],"category_scores_gemma":[0.0001678341,0.0001597869,0.0002839253,0.0002024278,0.0001755633,0.0002209008,0.000245876,0.000540339,0.0003712279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004706738,"about_ca_system_score_gemma":0.0004174662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009019846,"about_ca_topic_score_gemma":0.002056749,"domain_scores_codex":[0.999934,0.000007895999,0.000003589677,0.00001446837,0.00002338555,0.00001675806],"domain_scores_gemma":[0.9999665,0.000006884715,0.0000105716,0.000002251021,0.000006141856,0.000007562448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0012816,0.0003517606,0.000372556,0.0003139725,0.00005745601,0.0001988449,0.00002709535,0.0384368,0.9344124,0.001527189,0.0007037303,0.02231655],"study_design_scores_gemma":[0.0007689485,0.003113905,0.001375729,0.00003951278,0.0001646202,0.0003011737,0.00007393273,0.06579365,0.9147481,0.0005983491,0.01296713,0.0000548111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754577,0.00648155,0.01054684,0.0003460504,0.0001022019,0.0001460049,0.0005802786,0.000207669,0.006131746],"genre_scores_gemma":[0.9861752,0.002754467,0.008162742,0.00009661613,0.00001099759,0.00007132558,0.0004566707,0.0000435601,0.002228418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002269389,"threshold_uncertainty_score":0.007591844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07416520894600544,"score_gpt":0.405059304450424,"score_spread":0.3308940955044186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}