{"id":"W4406182716","doi":"10.1111/cns.70214","title":"Locus Coeruleus Degeneration in Essential Tremor With Mild Cognitive Impairment: A Neuromelanin <scp>MRI</scp> Study","year":2025,"lang":"en","type":"article","venue":"CNS Neuroscience & Therapeutics","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science and Technology Program of Zhejiang Province; China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Neuromelanin; Locus coeruleus; Magnetic resonance imaging; Cognition; Medicine; Audiology; Internal medicine; Psychology; Neuroscience; Cognitive impairment; Cognitive decline; Substantia nigra; Disease; Radiology; Parkinson's disease; Central nervous system; Dementia","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001086207,0.0002691054,0.0003153214,0.0002276843,0.0001929586,0.00008606994,0.0001715494,0.00006527088,0.000005733936],"category_scores_gemma":[0.00004534094,0.0001935552,0.00006002918,0.001083622,0.0002543191,0.000108737,0.00006663812,0.0002788107,0.000009971661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003861582,"about_ca_system_score_gemma":0.0001462336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002140477,"about_ca_topic_score_gemma":0.00006780202,"domain_scores_codex":[0.9980668,0.0001543982,0.000272788,0.0006815058,0.0003838259,0.0004406406],"domain_scores_gemma":[0.9993137,0.0001416473,0.0000824119,0.0002776606,0.00007969232,0.0001049036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001280394,0.01827185,0.9033722,0.00005807108,0.0001208566,0.002331219,0.002282775,0.0003692675,0.06593287,0.0002216882,0.000211811,0.005546982],"study_design_scores_gemma":[0.01357006,0.01119552,0.9522035,0.00008844929,0.0006406686,0.00004299466,0.001128178,0.003126088,0.01690825,0.0003040145,0.0006164711,0.000175839],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961073,0.0001554856,0.0003917487,0.0007074442,0.0002474082,0.001542914,0.0000122241,0.00007359922,0.0007618751],"genre_scores_gemma":[0.9900323,0.0001081717,0.00002635997,0.008947166,0.00002242127,0.00008809722,0.000007497997,0.00002073765,0.0007472688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04902462,"threshold_uncertainty_score":0.7892953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02884009749518704,"score_gpt":0.3079337297445054,"score_spread":0.2790936322493184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}