{"id":"W4406182972","doi":"10.1021/acs.jproteome.4c00773","title":"Comparative Analysis of Transcriptomic and Proteomic Expression between Two Non-Small Cell Lung Cancer Subtypes","year":2025,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; University of Oxford; University of Southampton; Cancer Research UK","keywords":"Adenocarcinoma; Biology; Lung cancer; Transcriptome; Druggability; Cancer research; Cancer; Gene expression profiling; Proteomics; Oncology; Bioinformatics; Gene expression; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000761245,0.00009062395,0.0003444362,0.0004897179,0.00009090666,0.0000272375,0.0002261285,0.00008183684,0.00002066731],"category_scores_gemma":[0.00001918194,0.00006923355,0.0001327985,0.0005523466,0.0001187269,0.000007938184,0.00004803333,0.0002199159,2.612788e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005596603,"about_ca_system_score_gemma":0.0004725475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001406319,"about_ca_topic_score_gemma":0.00005632494,"domain_scores_codex":[0.998892,0.0001895162,0.0003475719,0.0001807681,0.0002074633,0.0001826764],"domain_scores_gemma":[0.9989775,0.00002951761,0.0001816964,0.0001966788,0.0005430938,0.00007151096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001877183,0.00005137236,0.04516445,0.00008352654,0.0004584354,5.956088e-7,0.000233418,0.0002651561,0.9528362,0.000005544212,0.0002672586,0.00044637],"study_design_scores_gemma":[0.0007497363,0.0002457109,0.06404254,0.00009809778,0.0002268283,4.887401e-7,0.0001489583,0.0004460681,0.9331958,0.00002896881,0.0007510773,0.000065778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911907,0.003662668,0.004101467,0.0001771945,0.00002620591,0.0004833488,0.00002691695,9.134871e-7,0.0003305359],"genre_scores_gemma":[0.9971291,0.001067444,0.0009089924,0.000005248147,0.0000998155,0.00007047354,0.000006190916,0.000005441127,0.0007073353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0196404,"threshold_uncertainty_score":0.2823262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04386721563655785,"score_gpt":0.4054519610979102,"score_spread":0.3615847454613523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}