{"id":"W4406185797","doi":"10.1016/j.gendis.2025.101519","title":"Restriction of YWHAB-mediated YAP cytoplasmic retention is a novel mechanism underlying stemness maintenance and chemoresistance in ovarian cancer peritoneal metastasis","year":2025,"lang":"en","type":"article","venue":"Genes & Diseases","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundamental Research Funds for the Central Universities; National Natural Science Foundation of China; Dalian University of Technology; Organisation Canadienne des Physiciens Médicaux","keywords":"Ovarian cancer; Metastasis; Cancer research; Mechanism (biology); Cancer; Cytoplasm; Medicine; Biology; Oncology; Internal medicine; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001053639,0.0001516497,0.0002041242,0.0001024041,0.00007981718,0.00002112966,0.0001021532,0.0001058149,0.000007999086],"category_scores_gemma":[0.00005588366,0.0001523964,0.00007417754,0.0002515379,0.00006151074,0.000008259423,0.0000557926,0.00005220581,4.707788e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003320178,"about_ca_system_score_gemma":0.0001786003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002679617,"about_ca_topic_score_gemma":0.0002000986,"domain_scores_codex":[0.9989781,0.00004907327,0.0002553736,0.0003891864,0.0001189932,0.0002092416],"domain_scores_gemma":[0.9995008,0.00001797344,0.0001088782,0.0002132732,0.00009758061,0.0000615441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002305254,0.00007914388,0.006882866,0.0001617124,0.0000702535,0.000002864303,0.00004374756,0.00006002285,0.9899902,0.0002771632,0.00005041223,0.002151063],"study_design_scores_gemma":[0.002401442,0.0001411975,0.08972942,0.0005109278,0.0002607082,0.000004515791,0.0007366954,0.001214256,0.9020801,0.0009317029,0.001555746,0.0004332652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867862,0.007378025,0.004881226,0.0001650209,0.0001580612,0.000186428,0.0003970554,0.00001314173,0.00003478138],"genre_scores_gemma":[0.9969403,0.002148366,0.000323326,0.0001262307,0.00003569598,0.00007813728,0.0001266087,0.00001403677,0.0002073253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0879101,"threshold_uncertainty_score":0.6214546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02086791615451655,"score_gpt":0.2736352319055766,"score_spread":0.2527673157510601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}