{"id":"W4406186905","doi":"10.54254/2753-8818/2024.19396","title":"Amyloid, Tau, and ApoE: Revisiting Hypotheses of Alzheimer's Disease","year":2025,"lang":"en","type":"article","venue":"Theoretical and Natural Science","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Humber Polytechnic","funders":"","keywords":"Apolipoprotein E; Amyloid (mycology); Alzheimer's disease; Disease; Psychology; Medicine; Neuroscience; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002938228,0.001056839,0.001560404,0.002815401,0.0005702855,0.002573309,0.001352455,0.001365137,0.0009105726],"category_scores_gemma":[0.002215088,0.0002736309,0.0005635926,0.001970035,0.003321388,0.00586163,0.001480273,0.002541188,0.0003932808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001168564,"about_ca_system_score_gemma":0.002484441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001156989,"about_ca_topic_score_gemma":0.001534011,"domain_scores_codex":[0.9995118,0.0001704087,0.00007386754,0.00008630606,0.0001208717,0.00003674653],"domain_scores_gemma":[0.9988124,0.0008026968,0.00009642323,0.00003585629,0.0002059426,0.00004661941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003799667,0.0001550438,0.003333571,0.02839443,0.0003740317,0.003458423,0.005018612,0.001551338,0.007791974,0.1752011,0.01691823,0.7574233],"study_design_scores_gemma":[0.00003528508,0.0003678006,0.005662846,0.01364744,0.0004376766,0.005654307,0.004720448,0.0008669875,0.002192646,0.2700507,0.6962423,0.000121593],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001317369,0.9926872,0.0009049994,0.003293266,0.000753894,0.000005183699,0.00001120749,0.000006692581,0.001020147],"genre_scores_gemma":[0.008381196,0.9878054,0.0006999699,0.001282176,0.001414124,0.00001009576,0.00002141609,0.000002943548,0.00038275],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002938228,"threshold_uncertainty_score":0.01553899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269951446669202,"score_gpt":0.3152197090686317,"score_spread":0.3025201946019396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}