{"id":"W4406188883","doi":"10.3389/fnins.2024.1509543","title":"Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice","year":2025,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Morinda citrifolia extract uses","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Science and Technology Major Project","keywords":"CREB; Tropomyosin receptor kinase B; Depression (economics); Sexual dysfunction; Medicine; Psychology; Pharmacology; Internal medicine; Neurotrophic factors; Biology; Transcription factor; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009035696,0.0005363025,0.000322929,0.0004183227,0.0001596994,0.0001632975,0.0002340628,0.00028321,0.0009632022],"category_scores_gemma":[0.00006176742,0.0001228276,0.0003796869,0.0001341628,0.000204575,0.0002585134,0.0001733422,0.0008815267,0.0001322206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001984232,"about_ca_system_score_gemma":0.0002184202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009599366,"about_ca_topic_score_gemma":0.001732593,"domain_scores_codex":[0.9999504,0.000006071691,0.000004985438,0.00001062992,0.00001260749,0.00001524261],"domain_scores_gemma":[0.9999387,0.000002452937,0.00002468612,0.000003966796,0.000008094208,0.00002206755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001335595,0.0003878116,0.0005822589,0.0002596985,0.00003562566,0.00007627303,0.0000283882,0.00008991739,0.989233,0.0001590771,0.0001609111,0.007651317],"study_design_scores_gemma":[0.000770175,0.009560748,0.04707967,0.0001391453,0.000293042,0.0004962101,0.0001887229,0.002417142,0.9280118,0.0005321071,0.01046588,0.00004535713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896667,0.005355329,0.002180499,0.0004057959,0.00007171079,0.00006212814,0.0008435596,0.0001180358,0.001296133],"genre_scores_gemma":[0.9875607,0.004856464,0.003228529,0.0002417661,0.00002900132,0.0001369965,0.0007988579,0.00002051166,0.003127115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009632022,"threshold_uncertainty_score":0.003222287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01772606828721446,"score_gpt":0.2694649553761841,"score_spread":0.2517388870889697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}