{"id":"W4406193414","doi":"10.1183/23120541.00758-2024","title":"AeroVax: study protocol for a randomised, double-blind, placebo-controlled phase 2 trial to evaluate safety and immunogenicity of a next-generation COVID-19 vaccine delivered by inhaled aerosol to humans","year":2025,"lang":"en","type":"article","venue":"ERJ Open Research","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Ottawa Hospital; University of Ottawa; McMaster University; St. Joseph’s Healthcare Hamilton; McMaster University Medical Centre; Impact","funders":"Clinical Trials Fund, Canadian Institutes of Health Research","keywords":"Medicine; Immunogenicity; Coronavirus disease 2019 (COVID-19); Placebo; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Protocol (science); Double blind; Virology; Immunology; Internal medicine; Alternative medicine; Immune system; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.01993282,0.0004006522,0.001721092,0.0009619608,0.0008398744,0.0005250017,0.001106062,0.0002104482,0.0001786462],"category_scores_gemma":[0.007397731,0.0003178807,0.000259709,0.001665202,0.0001042686,0.0002681177,0.001144625,0.0006164456,0.00003030173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007153134,"about_ca_system_score_gemma":0.003831615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003430107,"about_ca_topic_score_gemma":0.001946855,"domain_scores_codex":[0.9924812,0.001976459,0.001597943,0.00122703,0.001767178,0.0009501539],"domain_scores_gemma":[0.9942931,0.002020075,0.0001910251,0.001145903,0.001970332,0.0003795726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.730587,0.003316571,0.0001028382,0.0002647254,0.0006047474,0.00002296378,0.0009891134,0.000007567535,0.2517134,0.00003005368,0.0105254,0.001835624],"study_design_scores_gemma":[0.8781431,0.01406592,0.000007736129,0.0001156516,0.000179174,0.000003868806,0.000661034,0.001732662,0.08709565,0.00002348093,0.0177328,0.0002389619],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.4870069,0.00003787976,0.001136579,0.001713971,0.000043809,0.5093647,0.00004576737,0.00002283889,0.0006275572],"genre_scores_gemma":[0.2290634,0.000002343061,0.0002827422,0.004238204,0.0001897785,0.7644588,0.00003763627,0.0000499164,0.001677192],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.2579436,"threshold_uncertainty_score":0.9999273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2958832356511237,"score_gpt":0.5471504080146362,"score_spread":0.2512671723635125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}