{"id":"W4406193414","doi":"10.1183/23120541.00758-2024","title":"AeroVax: study protocol for a randomised, double-blind, placebo-controlled phase 2 trial to evaluate safety and immunogenicity of a next-generation COVID-19 vaccine delivered by inhaled aerosol to humans","year":2025,"lang":"en","type":"article","venue":"ERJ Open Research","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Ottawa Hospital; University of Ottawa; McMaster University; St. Joseph’s Healthcare Hamilton; McMaster University Medical Centre; Impact","funders":"Clinical Trials Fund, Canadian Institutes of Health Research","keywords":"Medicine; Immunogenicity; Coronavirus disease 2019 (COVID-19); Placebo; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Protocol (science); Double blind; Virology; Immunology; Internal medicine; Alternative medicine; Immune system; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01823907,0.008253889,0.009997294,0.0016082,0.002807442,0.002832903,0.003649397,0.008467849,0.06882735],"category_scores_gemma":[0.01435816,0.003370769,0.003241537,0.001774779,0.004509788,0.004081668,0.001778242,0.008936586,0.01842587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002620728,"about_ca_system_score_gemma":0.008801436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001024897,"about_ca_topic_score_gemma":0.002663034,"domain_scores_codex":[0.9880645,0.006232812,0.001069624,0.001656494,0.001289974,0.001686567],"domain_scores_gemma":[0.9927452,0.001374808,0.001638997,0.001051108,0.001162248,0.002027652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9691646,0.01001694,0.0002895176,0.003397933,0.000466558,0.0000904652,0.0001034754,0.0005304992,0.002007626,0.001076632,0.004648098,0.008207671],"study_design_scores_gemma":[0.9460227,0.04016412,0.0006370124,0.0003790339,0.0002187304,0.00002744461,0.00002743003,0.0005232094,0.000365075,0.0008655977,0.01072584,0.00004377129],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.00771956,0.0005363932,0.001693741,0.0002850984,0.0007332357,0.9855782,0.001595692,0.0001630992,0.001694964],"genre_scores_gemma":[0.010303,0.00035865,0.002264373,0.0005448979,0.0002076303,0.9842722,0.0004119577,0.00001704221,0.001620137],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.06882735,"threshold_uncertainty_score":0.2302504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2958832356511237,"score_gpt":0.5471504080146362,"score_spread":0.2512671723635125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}