{"id":"W4406198898","doi":"10.1093/hmg/ddae200","title":"Transcriptomic analysis of human cartilage identified potential therapeutic targets for hip osteoarthritis","year":2025,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Government of Newfoundland and Labrador; Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research; Memorial University of Newfoundland; Research and Development Corporation of Newfoundland and Labrador; Arthritis Society","keywords":"Osteoarthritis; Cartilage; Transcriptome; Biology; Extracellular matrix; Internal medicine; Bioinformatics; Medicine; Gene; Pathology; Gene expression; Genetics; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003965954,0.0002654005,0.0004912129,0.0009755252,0.0002166004,0.0004001677,0.00010468,0.0002033356,0.000785734],"category_scores_gemma":[0.0004132954,0.00009078751,0.0003786763,0.0009710371,0.0002065601,0.0001456217,0.0002277117,0.0002239243,0.0001661143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002766512,"about_ca_system_score_gemma":0.000470511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006097,"about_ca_topic_score_gemma":0.001567043,"domain_scores_codex":[0.9997523,0.00004142962,0.00002043956,0.00005365223,0.0000918451,0.00004013475],"domain_scores_gemma":[0.9998229,0.00004147861,0.00006037433,0.00001182153,0.00004256348,0.0000208189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008916,0.00005601702,0.03985705,0.000513759,0.0001249564,0.0002938591,0.0000822306,0.0005757423,0.9338464,0.0001387851,0.0003575274,0.0232621],"study_design_scores_gemma":[0.00007422308,0.001340988,0.702087,0.0001719558,0.0005415987,0.0017201,0.0006070337,0.005746887,0.2778327,0.0005596598,0.009279284,0.00003856743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765479,0.01392328,0.003368023,0.0002374887,0.00005434394,0.00008194921,0.004514141,0.00005858177,0.00121435],"genre_scores_gemma":[0.9857757,0.005225381,0.004148956,0.0001934837,0.000028139,0.00006548389,0.003517414,0.00001121992,0.00103441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001006097,"threshold_uncertainty_score":0.002628565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01461948525955894,"score_gpt":0.2915103267772113,"score_spread":0.2768908415176524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}