{"id":"W4406201329","doi":"10.1002/alz.088450","title":"A DAT1 gene and APOE ε4 interaction is associated with apathy and structural brain changes in Alzheimer’s Disease","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Western University","funders":"","keywords":"Apathy; Neuroimaging; Apolipoprotein E; Dementia; Single-nucleotide polymorphism; Psychology; Alzheimer's disease; Neuroscience; Disease; Medicine; Atrophy; Cognition; Psychiatry; Internal medicine; Genetics; Gene; Biology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009933241,0.0005237457,0.0005775262,0.0007621962,0.0005748108,0.0007750859,0.0004576262,0.0005151446,0.002979415],"category_scores_gemma":[0.002681487,0.0002905567,0.000885526,0.0007773349,0.0003501239,0.0002097421,0.0004091798,0.0007084622,0.0001800229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002147548,"about_ca_system_score_gemma":0.0003178692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004375239,"about_ca_topic_score_gemma":0.003416768,"domain_scores_codex":[0.9993506,0.0003326733,0.00005907791,0.000129298,0.00007845577,0.00004987828],"domain_scores_gemma":[0.9978428,0.0009557749,0.0006668077,0.0001656806,0.0001310382,0.0002377578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001564051,0.0001246859,0.9923232,0.00002295573,0.0007844155,0.0004066697,0.00009681265,0.0002642639,0.001739291,0.00007003003,0.0001160922,0.002487673],"study_design_scores_gemma":[0.00005156225,0.0002040254,0.9957945,0.00000764475,0.0003745199,0.0008413505,0.0001045594,0.00191304,0.0003321629,0.0002412597,0.000126841,0.0000084418],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993877,0.0001244533,0.0001666374,0.00005517437,0.000004553001,0.000002510599,0.0001001471,0.000004874526,0.0001538721],"genre_scores_gemma":[0.9995734,0.00002693472,0.000152162,0.00001277809,0.000006688796,0.000002357861,0.00008141009,0.000001936755,0.0001423445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004375239,"threshold_uncertainty_score":0.009967208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03435187102653974,"score_gpt":0.321341415495551,"score_spread":0.2869895444690112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}