{"id":"W4406201347","doi":"10.1002/alz.091850","title":"Clinical evaluation of a plasma Neurofilament Light chain electrochemiluminescence immunoassay in Alzheimer’s disease","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Internal medicine; Biomarker; Immunoassay; Disease; Alzheimer's disease; Neuropathology; Oncology; Montreal Cognitive Assessment; Cognitive impairment; Pathology; Immunology; Antibody; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000925444,0.0001933621,0.000191106,0.00007141163,0.00004398281,0.00001952191,0.0001857629,0.0001575415,0.00003822961],"category_scores_gemma":[0.00006728467,0.0001706662,0.0001642735,0.0001852067,0.00009942982,0.000006275897,0.0001460778,0.000183479,0.00002054438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004234357,"about_ca_system_score_gemma":0.0001820223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000125747,"about_ca_topic_score_gemma":0.00001896584,"domain_scores_codex":[0.9982036,0.0002044881,0.0005113055,0.0004957795,0.0003124496,0.0002723912],"domain_scores_gemma":[0.999375,0.00002283016,0.00008797196,0.000321712,0.0001132705,0.00007917997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004339461,0.0007679323,0.01496618,0.00003717725,0.02182261,0.00003832593,0.0002677575,0.00006090556,0.7312786,0.0003450143,0.01456291,0.2154187],"study_design_scores_gemma":[0.001698151,0.0004696783,0.01882763,0.0001831235,0.02267069,0.000009435036,0.00008199509,0.006775348,0.9110478,0.0001295969,0.03750908,0.0005974476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3747911,0.6219969,0.00003946517,0.0007850344,0.0007950926,0.0004754138,0.000008704072,0.00002372825,0.001084525],"genre_scores_gemma":[0.9962393,0.003178954,0.0001584927,0.0001030586,0.0001456726,0.00005551319,0.00008216639,0.00002415894,0.00001270448],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6214482,"threshold_uncertainty_score":0.6959564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02916085188813677,"score_gpt":0.3223757501616324,"score_spread":0.2932148982734957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}